Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability
dc.contributor.author
Richetto, Juliet
dc.contributor.author
Meyer, Urs
dc.date.accessioned
2021-01-14T16:28:30Z
dc.date.available
2020-12-24T03:44:02Z
dc.date.available
2021-01-14T16:28:30Z
dc.date.issued
2021-02-01
dc.identifier.issn
0006-3223
dc.identifier.issn
1873-2402
dc.identifier.other
10.1016/j.biopsych.2020.03.008
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/458515
dc.identifier.doi
10.3929/ethz-b-000458515
dc.description.abstract
Epigenetic modifications are increasingly recognized to play a role in the etiology and pathophysiology of schizophrenia and other psychiatric disorders with developmental origins. Here, we summarize clinical and preclinical findings of epigenetic alterations in schizophrenia and relevant disease models and discuss their putative origin. Recent findings suggest that certain schizophrenia risk loci can influence stochastic variation in gene expression through epigenetic processes, highlighting the intricate interaction between genetic and epigenetic control of neurodevelopmental trajectories. In addition, a substantial portion of epigenetic alterations in schizophrenia and related disorders may be acquired through environmental factors and may be manifested as molecular “scars.” Some of these scars can influence brain functions throughout the entire lifespan and may even be transmitted across generations via epigenetic germline inheritance. Epigenetic modifications, whether caused by genetic or environmental factors, are plausible molecular sources of phenotypic heterogeneity and offer a target for therapeutic interventions. The further elucidation of epigenetic modifications thus may increase our knowledge regarding schizophrenia’s heterogeneous etiology and pathophysiology and, in the long term, may advance personalized treatments through the use of biomarker-guided epigenetic interventions.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2020-03-28
ethz.journal.title
Biological Psychiatry
ethz.journal.volume
89
en_US
ethz.journal.issue
3
en_US
ethz.journal.abbreviated
Biol Psychiatry
ethz.pages.start
215
en_US
ethz.pages.end
226
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-12-24T03:44:14Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-01-14T16:28:41Z
ethz.rosetta.lastUpdated
2022-03-29T04:50:36Z
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true
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Review Article [4069]