The Antibacterial Drug Candidate SBC3 is a Potent Inhibitor of Bacterial Thioredoxin Reductase
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Date
2021-03-16Type
- Journal Article
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Cited 8 times in
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Abstract
Antibiotic resistance is a growing problem for public health and associated with increasing economic costs and mortality rates. Silver and silver-related compounds have been used for centuries due to their antimicrobial properties. In this work, we show that 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate/NHC*-Ag-OAc (SBC3) is a reversible, high affinity inhibitor of E. coli thioredoxin reductase (TrxR; K-i=10.8 +/- 1.2 nM). Minimal inhibition concentration (MIC) tests with different E. coli and P. aeruginosa strains demonstrated that SBC3 can efficiently inhibit bacterial cell growth, especially in combination with established antibiotics like gentamicin. Our results show that SBC3 is a promising antibiotic drug candidate targeting bacterial TrxR. Show more
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publishedExternal links
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ChemBioChemVolume
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Publisher
WileySubject
antibiotic resistance; antibiotics; inhibitors; NHC-metal complexes; thioredoxin reductaseMore
Show all metadata
Citations
Cited 8 times in
Web of Science
Cited 10 times in
Scopus
ETH Bibliography
yes
Altmetrics