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dc.contributor.author
Ding, Chao
dc.contributor.author
Emmenegger, Vishalini
dc.contributor.author
Schaffrath, Kim
dc.contributor.author
Feldmeyer, Dirk
dc.date.accessioned
2021-01-08T10:38:01Z
dc.date.available
2021-01-05T03:59:15Z
dc.date.available
2021-01-08T10:38:01Z
dc.date.issued
2021-01
dc.identifier.issn
1047-3211
dc.identifier.issn
1460-2199
dc.identifier.other
10.1093/cercor/bhaa201
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/459199
dc.identifier.doi
10.3929/ethz-b-000459199
dc.description.abstract
GABAergic interneurons in different cortical areas play important roles in diverse higher-order cognitive functions. The heterogeneity of interneurons is well characterized in different sensory cortices, in particular in primary somatosensory and visual cortex. However, the structural and functional properties of the medial prefrontal cortex (mPFC) interneurons have received less attention. In this study, a cluster analysis based on axonal projection patterns revealed four distinct clusters of L6 interneurons in rat mPFC: Cluster 1 interneurons showed axonal projections similar to Martinotti-like cells extending to layer 1, cluster 2 displayed translaminar projections mostly to layer 5, and cluster 3 interneuron axons were confined to the layer 6, whereas those of cluster 4 interneurons extend also into the white matter. Correlations were found between neuron location and axonal distribution in all clusters. Moreover, all cluster 1 L6 interneurons showed a monotonically adapting firing pattern with an initial high-frequency burst. All cluster 2 interneurons were fast-spiking, while neurons in cluster 3 and 4 showed heterogeneous firing patterns. Our data suggest that L6 interneurons that have distinct morphological and physiological characteristics are likely to innervate different targets in mPFC and thus play differential roles in the L6 microcircuitry and in mPFC-associated functions.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
axonal projection
en_US
dc.subject
interneurons
en_US
dc.subject
layer 6
en_US
dc.subject
medial prefrontal cortex
en_US
dc.title
Layer-Specific Inhibitory Microcircuits of Layer 6 Interneurons in Rat Prefrontal Cortex
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2020-08-22
ethz.journal.title
Cerebral Cortex
ethz.journal.volume
31
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Cereb. cortex
ethz.pages.start
32
en_US
ethz.pages.end
47
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-01-05T03:59:20Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-01-08T10:38:11Z
ethz.rosetta.lastUpdated
2021-02-15T23:00:47Z
ethz.rosetta.versionExported
true
ethz.COinS
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