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dc.contributor.author
Muri, Jonathan
dc.contributor.author
Kopf, Manfred
dc.date.accessioned
2021-06-07T14:40:31Z
dc.date.available
2021-01-07T20:04:06Z
dc.date.available
2021-01-08T11:22:57Z
dc.date.available
2021-06-07T14:40:31Z
dc.date.issued
2021-06
dc.identifier.issn
1474-1733
dc.identifier.issn
1471-1733
dc.identifier.other
10.1038/s41577-020-00478-8
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/460363
dc.description.abstract
Metabolic pathways and redox reactions are at the core of life. In the past decade(s), numerous discoveries have shed light on how metabolic pathways determine the cellular fate and function of lymphoid and myeloid cells, giving rise to an area of research referred to as immunometabolism. Upon activation, however, immune cells not only engage specific metabolic pathways but also rearrange their oxidation–reduction (redox) system, which in turn supports metabolic reprogramming. In fact, studies addressing the redox metabolism of immune cells are an emerging field in immunology. Here, we summarize recent insights revealing the role of reactive oxygen species (ROS) and the differential requirement of the main cellular antioxidant pathways, including the components of the thioredoxin (TRX) and glutathione (GSH) pathways, as well as their transcriptional regulator NF-E2-related factor 2 (NRF2), for proliferation, survival and function of T cells, B cells and macrophages. © Springer Nature Limited 2020.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.title
Redox regulation of immunometabolism
en_US
dc.type
Review Article
dc.date.published
2020-12-18
ethz.journal.title
Nature Reviews Immunology
ethz.journal.volume
21
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Nat Rev Immunol
ethz.pages.start
363
en_US
ethz.pages.end
381
en_US
ethz.grant
Redox regulation of the Immunometabolom
en_US
ethz.grant
Identification of PPARg target genes in macrophages and characterization of their functional roles
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03596 - Kopf, Manfred / Kopf, Manfred
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03596 - Kopf, Manfred / Kopf, Manfred
ethz.grant.agreementno
ETH-23 16-2
ethz.grant.agreementno
182829
ethz.grant.fundername
ETHZ
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100003006
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
ETH Grants
ethz.grant.program
Exzellenzbeitrag in Lebenswissenschaften
ethz.date.deposited
2021-01-07T20:04:10Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-06-07T14:40:47Z
ethz.rosetta.lastUpdated
2024-02-02T13:52:51Z
ethz.rosetta.versionExported
true
ethz.COinS
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