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dc.contributor.author
Bourojeni, Farin B.
dc.contributor.author
Zeilhofer, Hanns U.
dc.contributor.author
Kania, Artur
dc.date.accessioned
2021-01-08T10:41:01Z
dc.date.available
2021-01-08T03:47:49Z
dc.date.available
2021-01-08T10:41:01Z
dc.date.issued
2021-01
dc.identifier.other
10.1097/j.pain.0000000000002012
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/460401
dc.identifier.doi
10.3929/ethz-b-000460401
dc.description.abstract
Anterolateral system (AS) neurons relay nociceptive information from the spinal cord to the brain, protecting the body from harm by evoking a variety of behaviours and autonomic responses. The developmental programs that guide the connectivity of AS neurons remain poorly understood. Spinofugal axons cross the spinal midline in response to Netrin-1 signalling through its receptor deleted in colorectal carcinoma (DCC); however, the relevance of this canonical pathway to AS neuron development has only been demonstrated recently. Here, we disrupted Netrin-1:DCC signalling developmentally in AS neurons and assessed the consequences on the path finding of the different classes of spinofugal neurons. Many lamina I AS neurons normally innervate the lateral parabrachial nucleus and periaqueductal gray on the contralateral side. The loss of DCC in the developing spinal cord resulted in increased frequency of ipsilateral projection of spinoparabrachial and spinoperiaqueductal gray neurons. Given that contralateral spinofugal projections are largely associated with somatotopic representation of the body, changes in the laterality of AS spinofugal projections may contribute to reduced precision in pain localization observed in mice and humans carrying Dcc mutations.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Lippincott Williams and Wilkins
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
nociception
en_US
dc.subject
Aanterolateral
en_US
dc.subject
spinofugal
en_US
dc.subject
spinoparabrachial
en_US
dc.subject
spinothalamic
en_US
dc.subject
commissural
en_US
dc.subject
Hoxb8
en_US
dc.subject
DCC
en_US
dc.subject
Netrin-1
en_US
dc.subject
lamina
en_US
dc.title
Netrin-1 receptor DCC is required for the contralateral topography of lamina I anterolateral system neurons
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
ethz.journal.title
Pain
ethz.journal.volume
162
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
161
en_US
ethz.pages.end
175
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03742 - Zeilhofer, Hanns U. / Zeilhofer, Hanns U.
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03742 - Zeilhofer, Hanns U. / Zeilhofer, Hanns U.
ethz.date.deposited
2021-01-08T03:47:56Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-01-08T10:41:10Z
ethz.rosetta.lastUpdated
2022-03-29T04:44:19Z
ethz.rosetta.versionExported
true
ethz.COinS
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