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dc.contributor.author
Jarret, Abigail
dc.contributor.author
Jackson, Ruaidhrí
dc.contributor.author
Duizer, Coco
dc.contributor.author
Healy, Marc E.
dc.contributor.author
Zhao, Jun
dc.contributor.author
Rone, Joseph M.
dc.contributor.author
Bielecki, Piotr
dc.contributor.author
Sefik, Esen
dc.contributor.author
Roulis, Manolis
dc.contributor.author
Rice, Tyler
dc.contributor.author
Sivanathan, Kisha N.
dc.contributor.author
Zhou, Ting
dc.contributor.author
Solis, Angel G.
dc.contributor.author
Honcharova-Biletska, Hanna
dc.contributor.author
Vélez, Karelia
dc.contributor.author
Hartner, Saskia
dc.contributor.author
Low, Jun Siong
dc.contributor.author
Qu, Rihao
dc.contributor.author
de Zoete, Marcel R.
dc.contributor.author
Palm, Noah W.
dc.contributor.author
Ring, Aaron M.
dc.contributor.author
Weber, Achim
dc.contributor.author
Moor, Andreas
dc.contributor.author
Kluger, Yuval
dc.contributor.author
Nowarski, Roni
dc.contributor.author
Flavell, Richard A.
dc.date.accessioned
2021-10-15T07:43:25Z
dc.date.available
2021-01-13T07:43:37Z
dc.date.available
2021-02-22T10:50:33Z
dc.date.available
2021-03-02T06:45:53Z
dc.date.available
2021-10-15T07:43:25Z
dc.date.issued
2020-01-09
dc.identifier.issn
0092-8674
dc.identifier.issn
1097-4172
dc.identifier.other
10.1016/j.cell.2019.12.016
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/461890
dc.identifier.doi
10.3929/ethz-b-000461890
dc.description.abstract
Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, here, we show that the enteric nervous system (ENS) plays an essential and non-redundant role in governing the antimicrobial protein (AMP) response. Using confocal microscopy and single-molecule fluorescence in situ mRNA hybridization (smFISH) studies, we observed that intestinal neurons produce the pleiotropic cytokine IL-18. Strikingly, deletion of IL-18 from the enteric neurons alone, but not immune or epithelial cells, rendered mice susceptible to invasive Salmonella typhimurium (S.t.) infection. Mechanistically, unbiased RNA sequencing and single-cell sequencing revealed that enteric neuronal IL-18 is specifically required for homeostatic goblet cell AMP production. Together, we show that neuron-derived IL-18 signaling controls tissue-wide intestinal immunity and has profound consequences on the mucosal barrier and invasive bacterial killing. © 2019 Elsevier Inc.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Cell Press
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.title
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
en_US
dc.type
Journal Article
dc.rights.license
In Copyright - Non-Commercial Use Permitted
ethz.journal.title
Cell
ethz.journal.volume
180
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Cell
ethz.pages.start
50
en_US
ethz.pages.end
63.e12
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.publication.place
Cambridge, MA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::09711 - Moor, Andreas / Moor, Andreas
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::09711 - Moor, Andreas / Moor, Andreas
en_US
ethz.date.deposited
2021-01-13T07:43:44Z
ethz.source
FORM
ethz.eth
no
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-02-22T10:50:46Z
ethz.rosetta.lastUpdated
2021-02-22T10:50:46Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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