Show simple item record

dc.contributor.author
Blasche, Sonja
dc.contributor.author
Kim, Yongkyu
dc.contributor.author
Mars, Ruben A.T.
dc.contributor.author
Machado, Daniel
dc.contributor.author
Maansson, Maria
dc.contributor.author
Kafkia, Eleni
dc.contributor.author
Milanese, Alessio
dc.contributor.author
Zeller, Georg
dc.contributor.author
Teusink, Bas
dc.contributor.author
Nielsen, Jens
dc.contributor.author
Benes, Vladimir
dc.contributor.author
Neves, Rute
dc.contributor.author
Sauer, Uwe
dc.contributor.author
Patil, Kiran Raosaheb
dc.date.accessioned
2021-01-25T10:48:36Z
dc.date.available
2021-01-23T08:41:14Z
dc.date.available
2021-01-25T10:48:36Z
dc.date.issued
2021-02
dc.identifier.issn
2058-5276
dc.identifier.other
10.1038/s41564-020-00816-5
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/465010
dc.description.abstract
Microbial communities often undergo intricate compositional changes yet also maintain stable coexistence of diverse species. The mechanisms underlying long-term coexistence remain unclear as system-wide studies have been largely limited to engineered communities, ex situ adapted cultures or synthetic assemblies. Here, we show how kefir, a natural milk-fermenting community of prokaryotes (predominantly lactic and acetic acid bacteria) and yeasts (family Saccharomycetaceae), realizes stable coexistence through spatiotemporal orchestration of species and metabolite dynamics. During milk fermentation, kefir grains (a polysaccharide matrix synthesized by kefir microorganisms) grow in mass but remain unchanged in composition. In contrast, the milk is colonized in a sequential manner in which early members open the niche for the followers by making available metabolites such as amino acids and lactate. Through metabolomics, transcriptomics and large-scale mapping of inter-species interactions, we show how microorganisms poorly suited for milk survive in-and even dominate-the community, through metabolic cooperation and uneven partitioning between grain and milk. Overall, our findings reveal how inter-species interactions partitioned in space and time lead to stable coexistence. Using kefir as a natural model microbial ecosystem, the authors apply metabolomics, transcriptomics and large-scale mapping of inter-species interactions to study the drivers of stable coexistence of species in space and time.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.subject
Microbial communities
en_US
dc.subject
Systems biology
en_US
dc.title
Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community
en_US
dc.type
Journal Article
dc.date.published
2021-01-04
ethz.journal.title
Nature Microbiology
ethz.journal.volume
6
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Nat Microbiol
ethz.pages.start
196
en_US
ethz.pages.end
208
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03713 - Sauer, Uwe / Sauer, Uwe
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03713 - Sauer, Uwe / Sauer, Uwe
ethz.date.deposited
2021-01-23T08:41:18Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-01-25T10:48:46Z
ethz.rosetta.lastUpdated
2022-03-29T04:57:26Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Metabolic%20cooperation%20and%20spatiotemporal%20niche%20partitioning%20in%20a%20kefir%20microbial%20community&rft.jtitle=Nature%20Microbiology&rft.date=2021-02&rft.volume=6&rft.issue=1&rft.spage=196&rft.epage=208&rft.issn=2058-5276&rft.au=Blasche,%20Sonja&Kim,%20Yongkyu&Mars,%20Ruben%20A.T.&Machado,%20Daniel&Maansson,%20Maria&rft.genre=article&rft_id=info:doi/10.1038/s41564-020-00816-5&
 Search print copy at ETH Library

Files in this item

FilesSizeFormatOpen in viewer

There are no files associated with this item.

Publication type

Show simple item record