OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more

Open access
Date
2021-01-08Type
- Journal Article
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Cited 32 times in
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Abstract
OMA is an established resource to elucidate evolutionary relationships among genes from currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise orthologs, functional annotations, local and global gene order conservation (synteny) information, among many other functions. This update paper describes the reorganisation of the database into gene-, group- and genome-centric pages. Other new and improved features are detailed, such as reporting of the evolutionarily best conserved isoforms of alternatively spliced genes, the inferred local order of ancestral genes, phylogenetic profiling, better cross-references, fast genome mapping, semantic data sharing via RDF, as well as a special coronavirus OMA with 119 viruses from the Nidovirales order, including SARS-CoV-2, the agent of the COVID-19 pandemic. We conclude with improvements to the documentation of the resource through primers, tutorials and short videos. OMA is accessible at https://omabrowser.org. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000465012Publication status
publishedExternal links
Journal / series
Nucleic Acids ResearchVolume
Pages / Article No.
Publisher
Oxford University PressMore
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Citations
Cited 31 times in
Web of Science
Cited 32 times in
Scopus
ETH Bibliography
yes
Altmetrics