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dc.contributor.author
Post, Adrian
dc.contributor.author
Groothof, Dion
dc.contributor.author
Schutten, Joëlle C.
dc.contributor.author
Flores-Guerrero, Jose L.
dc.contributor.author
Swarte, J. Casper
dc.contributor.author
Douwes, Rianne M.
dc.contributor.author
Kema, Ido P.
dc.contributor.author
de Boer, Rudolf A.
dc.contributor.author
Garcia, Erwin
dc.contributor.author
Connelly, Marge A.
dc.contributor.author
Wallimann, Theo
dc.contributor.author
Dullaart, Robin P.F.
dc.contributor.author
Franssen, Casper F.M.
dc.contributor.author
Bakker, Stephan J.L.
dc.date.accessioned
2021-03-26T11:43:57Z
dc.date.available
2021-01-27T06:16:58Z
dc.date.available
2021-01-27T17:34:48Z
dc.date.available
2021-03-26T11:43:57Z
dc.date.issued
2021-04
dc.identifier.other
10.1111/cen.14396
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/465809
dc.identifier.doi
10.3929/ethz-b-000465809
dc.description.abstract
Background Type 2 diabetes is associated with both impaired insulin action at target tissues and impaired insulin secretion in pancreatic beta cells. Mitochondrial dysfunction may play a role in both insulin resistance and impaired insulin secretion. Plasma creatine has been proposed as a potential marker for mitochondrial dysfunction. We aimed to investigate the association between plasma creatine and incident type 2 diabetes. Methods We measured fasting plasma creatine concentrations by nuclear magnetic resonance spectroscopy in participants of the general population‐based PREVEND study. The study outcome was incident type 2 diabetes, defined as a fasting plasma glucose ≥7.0 mmol/L (126 mg/dl); a random sample plasma glucose ≥11.1 mmol/L (200 mg/dl); self‐report of a physician diagnosis or the use of glucose‐lowering medications based on a central pharmacy registration. Associations of plasma creatine with type 2 diabetes were quantified using Cox proportional hazards models and were adjusted for potential confounders. Results We included 4735 participants aged 52 ± 11 years, of whom 49% were male. Mean plasma creatine concentrations were 36.7 ± 17.6 µmol/L, with lower concentrations in males than in females (30.4 ± 15.1 µmol/L vs. 42.7 ± 17.7 µmol/L; p for difference <.001). During 7.3 [6.2–7.7] years of follow‐up, 235 (5.4%) participants developed type 2 diabetes. Higher plasma creatine concentrations were associated with an increased risk of incident type 2 diabetes (HR per SD change: 1.27 [95% CI: 1.11–1.44]; p < .001), independent of potential confounders. This association was strongly modified by sex (p interaction <.001). Higher plasma creatine was associated with an increased risk of incident type 2 diabetes in males (HR: 1.40 [1.17–1.67]; p < .001), but not in females (HR: 1.10 [0.90–1.34]; p = .37). Conclusion Fasting plasma creatine concentrations are lower in males than in females. Higher plasma creatine is associated with an increased risk of type 2 diabetes in males.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
creatine
en_US
dc.subject
general population
en_US
dc.subject
type 2 diabetes
en_US
dc.title
Plasma creatine and incident type 2 diabetes in a general population‐based cohort: The PREVEND study
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2020-12-21
ethz.journal.title
Clinical Endocrinology
ethz.journal.volume
94
en_US
ethz.journal.issue
4
en_US
ethz.pages.start
563
en_US
ethz.pages.end
574
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Hoboken, NJ
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-01-27T06:17:02Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-03-26T11:44:23Z
ethz.rosetta.lastUpdated
2021-03-26T11:44:23Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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