Role of Dietary Micronutrients on Gut Microbial Dysbiosis and Modulation in Inflammatory Bowel Disease
Metadata only
Date
2021-03Type
- Journal Article
Abstract
In patients with inflammatory bowel diseases (IBD), dietary micronutrient intake is low and deficiencies are common. Besides the host, also the gut microbiota require micronutrients and low levels may disturb its functioning. Multi‐omics studies indeed detected shifts in micronutrient‐dependent microbial pathways in IBD. It is however not clear whether micronutrients may alleviate inflammation directly, by modulating the immune system, or also indirectly, by modulating the structure and function of the gut microbiota. The latter seems of particular interest, since the gut microbiota is one of the future therapeutic targets in IBD.
A review of the most recent available literature on relevant micronutrients in context of IBD and gut microbiota was conducted. An overview per relevant micronutrient on its role on gut bacterial growth, metabolism and host–microbe interactions during gut inflammation is provided.
Dietary micronutrients have potential to be part of future personalized microbiome‐targeted therapies in IBD, considering both the micronutrient status of the host and the gut microbiota. However, cohort studies together with integrated multi‐scale studies are needed to understand the mechanisms of micronutrient–microbiome–host interactions in IBD and to evaluate efficacy and safety of dietary micronutrient treatment strategies. Show more
Publication status
publishedExternal links
Journal / series
Molecular Nutrition & Food ResearchVolume
Pages / Article No.
Publisher
Wiley‐VCHSubject
Gut inflammation; IBD; Microbiome; Minerals; VitaminsOrganisational unit
03626 - Lacroix, Christophe / Lacroix, Christophe
Funding
179307 - Deciphering the role of vitamins B9 and B12 as modulators of the human gut microbiota (SNF)
More
Show all metadata