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dc.contributor.author
Poulis, Nikolaos
dc.contributor.author
Zaytseva, Polina
dc.contributor.author
Gähwiler, Eric K.N.
dc.contributor.author
Motta, Sarah E.
dc.contributor.author
Fioretta, Emanuela S.
dc.contributor.author
Cesarovic, Nikola
dc.contributor.author
Falk, Volkmar
dc.contributor.author
Hoerstrup, Simon P.
dc.contributor.author
Emmert, Maximilian Y.
dc.date.accessioned
2021-02-19T10:29:43Z
dc.date.available
2021-01-28T18:18:52Z
dc.date.available
2021-02-19T10:29:43Z
dc.date.issued
2020-10
dc.identifier.issn
1477-9072
dc.identifier.issn
1744-8344
dc.identifier.other
10.1080/14779072.2020.1792777
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/466489
dc.description.abstract
Introduction The establishment of transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of severe aortic stenosis. However, with TAVI being approved for low-risk patients, valve durability is becoming of central importance. Here, we summarize how tissue engineered heart valves (TEHVs) may provide a clinically-relevant durable valve replacement compatible with TAVI. Areas covered Since its introduction, TAVI prostheses have advanced in design and development. However, TAVI bioprostheses are based on fixed xenogeneic materials prone to progressive degeneration. Transcatheter TEHVs may have the potential to overcome the drawbacks of current TAVI bioprostheses, with their remodeling, self-repair, and growth capacities. So far, performance and remodeling of transcatheter TEHV with in-situ regenerative potential were demonstrated in the low-pressure system, with acute performance proved in the systemic circulation. However, several challenges remain to be solved to ensure a safe clinical translation of TEHVs for TAVI approaches. Expert opinion With TAVI rapidly evolving, the establishment of long-term valve durability represents the top priority to reduce the rate of patient re-interventions, remove the associated risks and adverse events, and improve patients’ life quality worldwide. With long-term performance and remodeling proved, TEHVs may represent the next-generation technology for a life-long TAVI prosthesis.
en_US
dc.language.iso
en
en_US
dc.publisher
Informa
en_US
dc.subject
Aortic stenosis
en_US
dc.subject
Bioprostheses
en_US
dc.subject
Heart valve replacement
en_US
dc.subject
Remodeling
en_US
dc.subject
Tissue engineered heart valves
en_US
dc.title
Tissue engineered heart valves for transcatheter aortic valve implantation: current state, challenges, and future developments
en_US
dc.type
Review Article
dc.date.published
2020-09-23
ethz.journal.title
Expert Review of Cardiovascular Therapy
ethz.journal.volume
18
en_US
ethz.journal.issue
10
en_US
ethz.journal.abbreviated
Expert Rev Cardiovasc Ther
ethz.pages.start
681
en_US
ethz.pages.end
696
en_US
ethz.identifier.wos
ethz.identifier.pubmed
32791869
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02540 - Institut für Translationale Medizin / Institute of Translational Medicine::09667 - Falk, Volkmar / Falk, Volkmar
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02540 - Institut für Translationale Medizin / Institute of Translational Medicine::09667 - Falk, Volkmar / Falk, Volkmar
en_US
ethz.identifier.orcidWorkCode
87696514
ethz.date.deposited
2021-01-28T18:19:00Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-02-19T10:29:54Z
ethz.rosetta.lastUpdated
2022-03-29T05:18:47Z
ethz.rosetta.versionExported
true
ethz.COinS
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