Show simple item record

dc.contributor.author
Lee, Yong Ho
dc.contributor.author
Denton, Elliott
dc.contributor.author
Morandi, Bill
dc.date.accessioned
2021-07-29T09:09:18Z
dc.date.available
2021-02-01T10:44:29Z
dc.date.available
2021-02-12T14:55:04Z
dc.date.available
2021-06-08T10:16:52Z
dc.date.available
2021-06-08T11:52:27Z
dc.date.available
2021-07-29T09:09:18Z
dc.date.issued
2021-02
dc.identifier.issn
1755-4349
dc.identifier.issn
1755-4330
dc.identifier.other
10.1038/s41557-020-00621-x
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/467053
dc.identifier.doi
10.3929/ethz-b-000467053
dc.description.abstract
Hydroformylation, a reaction that installs both a C–H bond and an aldehyde group across an unsaturated substrate, is one of the most important catalytic reactions in both industry and academia. Given the synthetic importance of creating new C–C bonds, the development of carboformylation reactions, wherein a new C–C bond is formed instead of a C–H bond, would bear enormous synthetic potential to rapidly increase molecular complexity in the synthesis of valuable aldehydes. However, the demanding complexity inherent in a four-component reaction, utilizing an exogenous CO source, has made the development of a direct carboformylation reaction a formidable challenge. Here, we describe a palladium-catalysed strategy that uses readily available aroyl chlorides as a carbon electrophile and CO source, in tandem with a sterically congested hydrosilane, to perform a stereoselective carboformylation of alkynes. An extension of this protocol to four chemodivergent carbonylations further highlights the creative opportunity offered by this strategy in carbonylation chemistry.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.title
Palladium-catalysed carboformylation of alkynes using acid chlorides as a dual carbon monoxide and carbon source
en_US
dc.type
Journal Article
dc.rights.license
In Copyright - Non-Commercial Use Permitted
dc.date.published
2021-01-29
ethz.journal.title
Nature Chemistry
ethz.journal.volume
13
en_US
ethz.journal.issue
2
en_US
ethz.journal.abbreviated
Nat Chem
ethz.pages.start
123
en_US
ethz.pages.end
130
en_US
ethz.size
16 p. accepted version
en_US
ethz.version.deposit
acceptedVersion
en_US
ethz.grant
Shuttle Catalysis for Reversible Molecular Construction
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::09634 - Morandi, Bill / Morandi, Bill
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::09634 - Morandi, Bill / Morandi, Bill
en_US
ethz.grant.agreementno
757608
ethz.grant.fundername
EC
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.program
H2020
ethz.date.deposited
2021-02-01T10:44:36Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.date.embargoend
2021-07-28
ethz.rosetta.installDate
2021-02-12T14:55:21Z
ethz.rosetta.lastUpdated
2021-02-12T14:55:21Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Palladium-catalysed%20carboformylation%20of%20alkynes%20using%20acid%20chlorides%20as%20a%20dual%20carbon%20monoxide%20and%20carbon%20source&rft.jtitle=Nature%20Chemistry&rft.date=2021-02&rft.volume=13&rft.issue=2&rft.spage=123&rft.epage=130&rft.issn=1755-4349&1755-4330&rft.au=Lee,%20Yong%20Ho&Denton,%20Elliott&Morandi,%20Bill&rft.genre=article&rft_id=info:doi/10.1038/s41557-020-00621-x&
 Search print copy at ETH Library

Files in this item

Thumbnail

Publication type

Show simple item record