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dc.contributor.author
Weber, Ines
dc.contributor.author
Derron, Nina
dc.contributor.author
Königstein, Karsten
dc.contributor.author
Gerber, Philipp A.
dc.contributor.author
Güntner, Andreas
dc.contributor.author
Pratsinis, Sotiris E.
dc.date.accessioned
2021-02-23T09:58:01Z
dc.date.available
2021-02-23T07:48:22Z
dc.date.available
2021-02-23T09:58:01Z
dc.date.issued
2021
dc.identifier.other
10.1002/smsc.202100004
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/470989
dc.description.abstract
Mobile health technologies can provide routinely and on‐demand information to manage metabolic diseases (e.g., diabetes, obesity) and optimize their treatment (e.g., exercise or dieting). Most promising is breath acetone monitoring to track lipolysis and complement standard glucose monitoring. Yet, accurate quantification of acetone down to parts‐per‐billion (ppb) is difficult with compact and mobile devices in the presence of interferants at comparable or higher concentrations. Here, a low‐cost detector that quantifies end‐tidal acetone during exercise and rest (challenging since fine alterations need to be resolved) is presented with excellent bias (25 ppb) and unprecedented precision (169 ppb) in 146 breath samples. It combines a flame‐made Pt/Al2O3 catalyst with a chemoresistive Si/WO3 sensor. The detector is robust against order of magnitude higher ethanol concentrations from disinfection and exercise‐driven endogenous breath isoprene ones, as validated by mass spectrometry. This detector accurately tracked the individual lipolysis dynamics in all volunteers, as confirmed by blood ketone measurements. It can be integrated readily into handheld devices for personalized metabolic assessment at home, in gyms and clinics.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
Nanotechnology
en_US
dc.subject
Electronics
en_US
dc.subject
Sensor
en_US
dc.subject
Medicine
en_US
dc.title
Monitoring Lipolysis by Sensing Breath Acetone down to ppb
en_US
dc.type
Journal Article
dc.date.published
2021-02-21
ethz.journal.title
Small Science
ethz.pages.start
2100004
en_US
ethz.size
26 p.
en_US
ethz.publication.place
Weineim
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02668 - Inst. f. Energie- und Verfahrenstechnik / Inst. Energy and Process Engineering::03510 - Pratsinis, Sotiris E. / Pratsinis, Sotiris E.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02668 - Inst. f. Energie- und Verfahrenstechnik / Inst. Energy and Process Engineering::03510 - Pratsinis, Sotiris E. / Pratsinis, Sotiris E.
en_US
ethz.date.deposited
2021-02-23T07:48:32Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.exportRequired
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Monitoring%20Lipolysis%20by%20Sensing%20Breath%20Acetone%20down%20to%20ppb&rft.jtitle=Small%20Science&rft.date=2021&rft.spage=2100004&rft.au=Weber,%20Ines&Derron,%20Nina&K%C3%B6nigstein,%20Karsten&Gerber,%20Philipp%20A.&G%C3%BCntner,%20Andreas&rft.genre=article&
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