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dc.contributor.author
Leon Sampedro, Ricardo
dc.contributor.author
del Campo, Rosa
dc.contributor.author
Rodriguez‐Baños, Mercedes
dc.contributor.author
Lanza, Val F.
dc.contributor.author
José Pozuelo, María
dc.contributor.author
Francés‐Cuesta, Carlos
dc.contributor.author
Tedim, Ana P.
dc.contributor.author
Freitas, Ana R.
dc.contributor.author
Novais, Carla
dc.contributor.author
Peixe, Luísa
dc.contributor.author
Willems, Rob J. L.
dc.contributor.author
Corander, Jukka
dc.contributor.author
González Candelas, Fernando
dc.contributor.author
Baquero, Fernando
dc.contributor.author
Coque, Teresa M.
dc.date.accessioned
2021-03-11T15:58:15Z
dc.date.available
2021-03-08T16:00:22Z
dc.date.available
2021-03-11T15:58:15Z
dc.date.issued
2019-08
dc.identifier.issn
1462-2912
dc.identifier.issn
1462-2920
dc.identifier.other
10.1111/1462-2920.14702
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/473473
dc.description.abstract
Wild birds have been suggested to be reservoirs of antimicrobial resistant and/or pathogenic Enterococcus faecalis (Efs) strains, but the scarcity of studies and available sequences limit our understanding of the population structure of the species in these hosts. Here, we analysed the clonal and plasmid diversity of 97 Efs isolates from wild migratory birds. We found a high diversity, with most sequence types (STs) being firstly described here, while others were found in other hosts including some predominant in poultry. We found that pheromone‐responsive plasmids predominate in wild bird Efs while 35% of the isolates entirely lack plasmids. Then, to better understand the ecology of the species, the whole genome of fivestrains with known STs (ST82, ST170, ST16 and ST55) were sequenced and compared with all the Efs genomes available in public databases. Using several methods to analyse core and accessory genomes (AccNET, PLACNET, hierBAPS and PANINI), we detected differences in the accessory genome of some lineages (e.g. ST82) demonstrating specific associations with birds. Conversely, the genomes of other Efs lineages exhibited divergence in core and accessory genomes, reflecting different adaptive trajectories in various hosts. This pangenome divergence, horizontal gene transfer events and occasional epidemic peaks could explain the population structure of the species. © 2019 Society for Applied Microbiology and John Wiley & Sons Ltd.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.title
Phylogenomics of Enterococcus faecalis from wild birds: new insights into host‐associated differences in core and accessory genomes of the species
en_US
dc.type
Journal Article
dc.type
Journal Article
dc.date.published
2019-06-04
ethz.journal.title
Environmental Microbiology
ethz.journal.volume
21
en_US
ethz.journal.issue
8
en_US
ethz.journal.abbreviated
Environ. microbiol.
ethz.pages.start
3046
en_US
ethz.pages.end
3062
en_US
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::09497 - Hall, Alex / Hall, Alex
en_US
ethz.identifier.orcidWorkCode
58144098
ethz.date.deposited
2021-03-08T16:00:32Z
ethz.source
FORM
ethz.eth
no
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-03-11T15:58:27Z
ethz.rosetta.lastUpdated
2021-03-11T15:58:27Z
ethz.rosetta.versionExported
true
ethz.COinS
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