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Date
2020-06Type
- Book Chapter
ETH Bibliography
yes
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Abstract
The spinal dorsal horn and its equivalent structure in the brainstem constitute the first sites of synaptic integration in the pain pathway. A huge body of literature exists on alterations in spinal nociceptive signal processing that contribute to the generation of exaggerated pain states and hence to what is generally known as “central sensitization.” Such mechanisms include changes in synaptic efficacy or neuronal excitability, which can be evoked by intense nociceptive stimulation or by inflammatory or neuropathic insults. Some of these changes cause alterations in the functional organization of dorsal horn sensory circuits, leading to abnormal pathological pain sensations. This article reviews the present state of this knowledge. It does not cover the contributions of astrocytes and microglia in detail as their functions are the subject of a separate chapter. Show more
Publication status
publishedExternal links
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Editor
Book title
The Oxford Handbook of the Neurobiology of PainPages / Article No.
Publisher
Oxford University PressSubject
pain; spinal cord; dorsal horn; plasticity; circuit; inflammation; neuropathy; GABA; glycine; disinhibitionOrganisational unit
03742 - Zeilhofer, Hanns U. / Zeilhofer, Hanns U.
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ETH Bibliography
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