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dc.contributor.author
Zeilhofer, Hanns U.
dc.contributor.author
Ganley, Robert
dc.contributor.editor
Wood, John N.
dc.date.accessioned
2021-03-10T12:18:48Z
dc.date.available
2021-03-10T12:17:35Z
dc.date.available
2021-03-10T12:18:48Z
dc.date.issued
2020-06
dc.identifier.isbn
978-0-19-086050-9
en_US
dc.identifier.other
10.1093/oxfordhb/9780190860509.013.23
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/473793
dc.description.abstract
The spinal dorsal horn and its equivalent structure in the brainstem constitute the first sites of synaptic integration in the pain pathway. A huge body of literature exists on alterations in spinal nociceptive signal processing that contribute to the generation of exaggerated pain states and hence to what is generally known as “central sensitization.” Such mechanisms include changes in synaptic efficacy or neuronal excitability, which can be evoked by intense nociceptive stimulation or by inflammatory or neuropathic insults. Some of these changes cause alterations in the functional organization of dorsal horn sensory circuits, leading to abnormal pathological pain sensations. This article reviews the present state of this knowledge. It does not cover the contributions of astrocytes and microglia in detail as their functions are the subject of a separate chapter.
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.subject
pain
en_US
dc.subject
spinal cord
en_US
dc.subject
dorsal horn
en_US
dc.subject
plasticity
en_US
dc.subject
circuit
en_US
dc.subject
inflammation
en_US
dc.subject
neuropathy
en_US
dc.subject
GABA
en_US
dc.subject
glycine
en_US
dc.subject
disinhibition
en_US
dc.title
Dorsal Horn Pain Mechanisms
en_US
dc.type
Book Chapter
dc.date.published
2019-04
ethz.book.title
The Oxford Handbook of the Neurobiology of Pain
en_US
ethz.pages.start
445
en_US
ethz.pages.end
470
en_US
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03742 - Zeilhofer, Hanns U. / Zeilhofer, Hanns U.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03742 - Zeilhofer, Hanns U. / Zeilhofer, Hanns U.
en_US
ethz.date.deposited
2020-01-27T09:34:55Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-03-10T12:17:45Z
ethz.rosetta.lastUpdated
2022-03-29T05:41:37Z
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/465514
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/394124
ethz.COinS
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