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dc.contributor.author
Ashauer, Roman
dc.contributor.author
Hintermeister, Anita
dc.contributor.author
O'Connor, Isabel
dc.contributor.author
Elumelu, Maline
dc.contributor.author
Hollender, Juliane
dc.contributor.author
Escher, Beate I.
dc.date.accessioned
2022-08-26T05:53:15Z
dc.date.available
2017-06-09T20:12:47Z
dc.date.available
2022-08-26T05:53:15Z
dc.date.issued
2012-03-20
dc.identifier.issn
0013-936X
dc.identifier.issn
1520-5851
dc.identifier.other
10.1021/es204611h
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/47411
dc.description.abstract
Bioaccumulation and biotransformation are key toxicokinetic processes that modify toxicity of chemicals and sensitivity of organisms. Bioaccumulation kinetics vary greatly among organisms and chemicals; thus, we investigated the influence of biotransformation kinetics on bioaccumulation in a model aquatic invertebrate using fifteen 14C-labeled organic xenobiotics from diverse chemical classes and physicochemical properties (1,2,3-trichlorobenzene, imidacloprid, 4,6-dinitro-o-cresol, ethylacrylate, malathion, chlorpyrifos, aldicarb, carbofuran, carbaryl, 2,4-dichlorophenol, 2,4,5-trichlorophenol, pentachlorophenol, 4-nitrobenzyl-chloride, 2,4-dichloroaniline, and sea-nine (4,5-dichloro-2-octyl-3-isothiazolone)). We detected and identified metabolites using HPLC with UV and radio-detection as well as high resolution mass spectrometry (LTQ-Orbitrap). Kinetics of uptake, biotransformation, and elimination of parent compounds and metabolites were modeled with a first-order one-compartment model. Bioaccumulation factors were calculated for parent compounds and metabolite enrichment factors for metabolites. Out of 19 detected metabolites, we identified seven by standards or accurate mass measurements and two via pathway analysis and analogies to other compounds. 1,2,3-Trichlorobenzene, imidacloprid, and 4,6-dinitro-o-cresol were not biotransformed. Dietary uptake contributed little to overall uptake. Differentiation between parent and metabolites increased accuracy of bioaccumulation parameters compared to total 14C measurements. Biotransformation dominated toxicokinetics and strongly affected internal concentrations of parent compounds and metabolites. Many metabolites reached higher internal concentrations than their parents, characterized by large metabolite enrichment factors.
en_US
dc.language.iso
en
en_US
dc.publisher
American Chemical Society
en_US
dc.title
Significance of Xenobiotic Metabolism for Bioaccumulation Kinetics of Organic Chemicals in Gammarus pulex
en_US
dc.type
Journal Article
dc.date.published
2012-02-09
ethz.journal.title
Environmental Science & Technology
ethz.journal.volume
46
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Environ. Sci. Technol.
ethz.pages.start
3498
en_US
ethz.pages.end
3508
en_US
ethz.identifier.wos
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.relation.isReferencedBy
10.1021/es301072j
ethz.date.deposited
2017-06-09T20:13:54Z
ethz.source
ECIT
ethz.identifier.importid
imp59364f137adf385618
ethz.ecitpid
pub:78070
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-12T21:44:35Z
ethz.rosetta.lastUpdated
2023-02-07T05:44:54Z
ethz.rosetta.versionExported
true
ethz.COinS
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