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dc.contributor.author
Stadnicka, Julita
dc.contributor.author
Schirmer, Kristin
dc.contributor.author
Ashauer, Roman
dc.date.accessioned
2022-08-25T13:44:03Z
dc.date.available
2017-06-09T20:12:49Z
dc.date.available
2022-08-25T13:44:03Z
dc.date.issued
2012-03-20
dc.identifier.issn
0013-936X
dc.identifier.issn
1520-5851
dc.identifier.other
10.1021/es2043728
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/47412
dc.description.abstract
Quantification of chemical toxicity continues to be generally based on measured external concentrations. Yet, internal chemical concentrations have been suggested to be a more suitable parameter. To better understand the relationship between the external and internal concentrations of chemicals in fish, and to quantify internal concentrations, we compared three toxicokinetic (TK) models with each other and with literature data of measured concentrations of 39 chemicals. Two one-compartment models, together with the physiologically based toxicokinetic (PBTK) model, in which we improved the treatment of lipids, were used to predict concentrations of organic chemicals in two fish species: rainbow trout (Oncorhynchus mykiss) and fathead minnow (Pimephales promelas). All models predicted the measured internal concentrations in fish within 1 order of magnitude for at least 68% of the chemicals. Furthermore, the PBTK model outperformed the one-compartment models with respect to simulating chemical concentrations in the whole body (at least 88% of internal concentrations were predicted within 1 order of magnitude using the PBTK model). All the models can be used to predict concentrations in different fish species without additional experiments. However, further development of TK models is required for polar, ionizable, and easily biotransformed compounds.
en_US
dc.language.iso
en
en_US
dc.publisher
American Chemical Society
en_US
dc.title
Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models
en_US
dc.type
Journal Article
dc.date.published
2012-02-10
ethz.journal.title
Environmental Science & Technology
ethz.journal.volume
46
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Environ. Sci. Technol.
ethz.pages.start
3273
en_US
ethz.pages.end
3280
en_US
ethz.identifier.wos
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-09T20:13:54Z
ethz.source
ECIT
ethz.identifier.importid
imp59364f138016842935
ethz.ecitpid
pub:78071
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-12T23:48:58Z
ethz.rosetta.lastUpdated
2022-03-28T10:30:35Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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