Show simple item record

dc.contributor.author
Kutomi, Osamu
dc.contributor.author
Zimmermann, Noemi
dc.contributor.author
Ishikawa, Takashi
dc.contributor.author
et al.
dc.date.accessioned
2021-03-15T18:53:38Z
dc.date.available
2021-03-15T05:19:49Z
dc.date.available
2021-03-15T18:53:38Z
dc.date.issued
2021-02-24
dc.identifier.issn
2375-2548
dc.identifier.other
10.1126/sciadv.abf3621
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/474372
dc.identifier.doi
10.3929/ethz-b-000474372
dc.description.abstract
Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule. Chlamydomonas lacking the DYBLUP ortholog shows both positive and negative phototaxis but becomes acclimated and attracted to high-intensity blue light. These results suggest a mechanism to avoid toxic strong light via direct photoregulation of dyneins.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
AAAS
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.title
A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2021-02-26
ethz.journal.title
Science Advances
ethz.journal.volume
7
en_US
ethz.journal.issue
9
en_US
ethz.journal.abbreviated
Sci Adv
ethz.pages.start
eabf3621
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-03-15T05:20:19Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-03-15T18:53:52Z
ethz.rosetta.lastUpdated
2022-03-29T05:47:29Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=A%20dynein-associated%20photoreceptor%20protein%20prevents%20ciliary%20acclimation%20to%20blue%20light&rft.jtitle=Science%20Advances&rft.date=2021-02-24&rft.volume=7&rft.issue=9&rft.spage=eabf3621&rft.issn=2375-2548&rft.au=Kutomi,%20Osamu&Zimmermann,%20Noemi&Ishikawa,%20Takashi&et%20al.&rft.genre=article&rft_id=info:doi/10.1126/sciadv.abf3621&
 Search print copy at ETH Library

Files in this item

Thumbnail

Publication type

Show simple item record