Treatment of Hepatic Fibrosis in Mice Based on Targeted Plasmonic Hyperthermia
Abstract
Liver fibrosis is a major health problem with multiple associated complications, which, to date, has no effective treatment. Hepatic stellate cells are the main responsible cells for fibrosis formation; upon their activation, excess accumulation of extracellular matrix and collagen deposits occurs. The mitogen platelet-derived growth factor (PDGF) and its receptor β (PDGFRβ) play a major role in hepatic stellate cells activation and are, therefore, promising targets for antifibrotic therapies. Gold nanorods hold great potential for diseased liver treatments, since their passive hepatic accumulation enhances active targeting strategies, hence increasing therapeutic efficiency. In addition, gold nanorods have photothermal properties that, combined with specific cell delivery, can be exploited to induce localized near-infrared light-mediated thermal ablation. Here, we demonstrate that gold nanorods coated with anti-PDGFRβ specifically target activated hepatic stellate cells in vivo. Additionally, gold nanorods-PDGFRβ-mediated photothermal therapy decreases fibrosis, hepatic inflammation, and hepatocyte injury in the experimental model of CCl4-induced liver fibrosis in mice. Show more
Publication status
publishedExternal links
Journal / series
ACS NanoVolume
Pages / Article No.
Publisher
American Chemical SocietySubject
Liver fibrosis; Photothermal therapy; Gold nanoparticles; PDGFRβ; Hepatic stellate cellsOrganisational unit
09698 - Quidant, Romain / Quidant, Romain
More
Show all metadata
ETH Bibliography
yes
Altmetrics