Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers

Open access
Date
2021-03-17Type
- Journal Article
Citations
Cited 27 times in
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Cited 30 times in
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ETH Bibliography
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Abstract
We describe a new functional group metathesis between aryl nitriles and aryl thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good to excellent yields. Furthermore, the cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility and utility in multistep synthesis. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000476419Publication status
publishedExternal links
Journal / series
Journal of the American Chemical SocietyVolume
Pages / Article No.
Publisher
American Chemical SocietyOrganisational unit
09634 - Morandi, Bill / Morandi, Bill
Funding
184658 - Catalytic synthesis of unprotected amines and heterocycles (SNF)
757608 - Shuttle Catalysis for Reversible Molecular Construction (EC)
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Show all metadata
Citations
Cited 27 times in
Web of Science
Cited 30 times in
Scopus
ETH Bibliography
yes
Altmetrics