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dc.contributor.author
Carranza Valencia, Alejandra
dc.contributor.author
Hirt, Reinhard
dc.contributor.author
Kampner, Doris
dc.contributor.author
Hiebl, Andreas
dc.contributor.author
Tichy, Alexander
dc.contributor.author
Rüthemann, Peter
dc.contributor.author
Pagitz, Maximilian
dc.date.accessioned
2021-04-19T15:09:39Z
dc.date.available
2021-04-02T02:50:10Z
dc.date.available
2021-04-19T15:09:39Z
dc.date.issued
2021
dc.identifier.other
10.1111/jvim.16064
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/477341
dc.identifier.doi
10.3929/ethz-b-000477341
dc.description.abstract
Background Inhalation treatment frequently is used in dogs and cats with chronic respiratory disease. Little is known however about the performance of delivery devices and the distribution of aerosolized drugs in the lower airways. Objective To assess the performance of 3 delivery devices and the impact of variable durations of inhalation on the pulmonary and extrapulmonary deposition of nebulized 99mtechnetium‐diethylenetriamine‐pentaacetic acid (99mTc‐DTPA). Animals Ten university‐owned healthy Beagle dogs. Methods Prospective crossover study. Dogs inhaled the radiopharmaceutical for 5 minutes either through the Aerodawg spacer with a custom‐made nose‐muzzle mask, the Aerochamber spacer with the same mask, or the Aerodawg spacer with its original nose mask. In addition, dogs inhaled for 1 and 3 minutes through the second device. Images were obtained by 2‐dimensional planar scintigraphy. Radiopharmaceutical uptake was calculated as an absolute value and as a fraction of the registered dose in the whole body. Results Mean (±SD) lung deposition for the 3 devices was 9.2% (±5.0), 11.4% (±4.9), and 9.3% (±4.6), respectively. Differences were not statistically significant. Uptake in pulmonary and extrapulmonary tissues was significantly lower after 1‐minute nebulization, but the mean pulmonary/extrapulmonary deposition ratio (0.38 ± 0.27) was significantly higher than after 5‐minute nebulization (0.16 ± 0.1; P = .03). No significant differences were detected after 3‐ and 5‐minute nebulization. Conclusion and Clinical Importance The performance of a pediatric spacer with a custom‐made mask is comparable to that of a veterinary device. One‐minute nebulization provides lower pulmonary uptake but achieves a better pulmonary/extrapulmonary deposition ratio than does 5‐minute nebulization.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
dog
en_US
dc.subject
inhalation
en_US
dc.subject
lung
en_US
dc.subject
radiopharmaceutical
en_US
dc.subject
scintigraphy
en_US
dc.title
Comparison of pulmonary deposition of nebulized 99mtechnetium‐diethylenetriamine‐pentaacetic acid through 3 inhalation devices in healthy dogs
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2021-02-24
ethz.journal.title
Journal of Veterinary Internal Medicine
ethz.journal.volume
35
en_US
ethz.journal.issue
2
en_US
ethz.pages.start
1080
en_US
ethz.pages.end
1087
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Malden, MA
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-04-02T02:50:14Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-04-19T15:09:49Z
ethz.rosetta.lastUpdated
2022-03-29T06:39:04Z
ethz.rosetta.versionExported
true
ethz.COinS
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