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dc.contributor.author
De Schoenmacker, Iara
dc.contributor.author
Berry, Carson
dc.contributor.author
Blouin, Jean-Sébastien
dc.contributor.author
Rosner, Jan
dc.contributor.author
Hubli, Michèle
dc.contributor.author
Jutzeler, Catherine R.
dc.contributor.author
Kramer, John L.K.
dc.date.accessioned
2021-04-12T13:14:07Z
dc.date.available
2021-04-03T02:56:52Z
dc.date.available
2021-04-12T13:14:07Z
dc.date.issued
2021-03-25
dc.identifier.issn
2045-2322
dc.identifier.other
10.1038/s41598-021-85819-w
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/477385
dc.identifier.doi
10.3929/ethz-b-000477385
dc.description.abstract
Previous studies comparing laser (LEPs) and contact heat evoked potentials (CHEPs) consistently reported higher amplitudes following laser compared to contact heat stimulation. However, none of the studies matched the perceived pain intensity, questioning if the observed difference in amplitude is due to biophysical differences between the two methods or a mismatch in stimulation intensity. The aims of the current study were twofold: (1) to directly compare the brain potentials induced by intensity matched laser and contact heat stimulation and (2) investigate how capsaicin-induced secondary hyperalgesia modulates LEPs and CHEPs. Twenty-one healthy subjects were recruited and measured at four experimental sessions: (1) CHEPs + sham, (2) LEPs + sham, (3) CHEPs + capsaicin, and (4) LEPs + capsaicin. Baseline (sham) LEPs latency was significantly shorter and amplitude significantly larger compared to CHEPs, even when matched for perceived pain. Neither CHEPs nor LEPs was sensitive enough to detect secondary hyperalgesia. These differences provide evidence that a faster heating rate results in an earlier and more synchronized LEPs than CHEPs. To our knowledge, this was the first study to match perceived intensity of contact heat and laser stimulations, revealing distinct advantages associated with the acquisition of LEPs.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Neuroscience
en_US
dc.subject
Physiology
en_US
dc.title
An intensity matched comparison of laser- and contact heat evoked potentials
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Scientific Reports
ethz.journal.volume
11
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Sci Rep
ethz.pages.start
6861
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Precision-Medicine for Neurological Disorders: Harnessing the Power of Big Data and Machine Learning for Biomarker Discovery and Drug Repositioning Strategies
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.grant.agreementno
186101
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Ambizione
ethz.date.deposited
2021-04-03T02:56:58Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-04-12T13:14:20Z
ethz.rosetta.lastUpdated
2022-03-29T06:29:57Z
ethz.rosetta.versionExported
true
ethz.COinS
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