Enantio- and Chemoselective Intramolecular Iridium-Catalyzed O-Allylation of Oximes
- Journal Article
A method for the enantio- and chemoselective iridium-catalyzed O-allylation of oximes is described. Kinetic resolution in an intramolecular setting provides enantioenriched oxime ethers and aliphatic allylic alcohols. The synthetic potential of the products generated with this method is showcased by their elaboration into a series of heterocyclic compounds and the formal synthesis of glycoprotein GP IIb-IIIa receptor antagonist (−)-roxifiban. Preliminary mechanistic experiments and computational data shed light on the remarkable chemoselectivity of the reaction. Show more
Journal / seriesOrganic Letters
Pages / Article No.
PublisherAmerican Chemical Society
Organisational unit03511 - Carreira, Erick M. / Carreira, Erick M.
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