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dc.contributor.author
Lese, Ioana
dc.contributor.author
Tsai, Catherine
dc.contributor.author
Matter, Martin T.
dc.contributor.author
Wüthrich, Tsering
dc.contributor.author
Scheer, Helene S.
dc.contributor.author
Taddeo, Adriano
dc.contributor.author
Constantinescu, Mihai A.
dc.contributor.author
Herrmann, Inge
dc.contributor.author
Olariu, Radu
dc.date.accessioned
2021-06-17T06:38:51Z
dc.date.available
2021-04-25T12:09:50Z
dc.date.available
2021-04-27T05:36:43Z
dc.date.available
2021-06-17T06:38:51Z
dc.date.issued
2021-06-14
dc.identifier.issn
2373-9878
dc.identifier.other
10.1021/acsbiomaterials.1c00283
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/480387
dc.identifier.doi
10.3929/ethz-b-000480387
dc.description.abstract
Seroma formation is a well-recognized postoperative complication for many plastic and general surgical procedures. Although various tissue adhesives and substances have been used in an effort to treat seroma formation, no therapies have been established clinically. Recently, the nano-bridging phenomenon has been introduced as a promising approach to achieve tissue adhesion and strong closure of deep skin wounds in rats. The present study seeks to assess the potential of nano-bridging beyond skin wounds in a rat model of seroma. Seromas were induced in 20 Lewis rats through bilateral axillary lymphadenectomy, excision of the latissimus dorsi and cutaneous maximus muscles, and disruption of dermal lymphatics. On postoperative day (POD) 7, the seroma was aspirated on both sides. A bioactive nanoparticle (NP) suspension based on zinc-doped strontium-substituted bioglass/ceria nanoparticles (NP group) or fibrin glue (fibrin group) was injected into the right seroma cavity, while the left side was left untreated. On POD 14, the NP group showed complete remission (no seromas at all), while the fibrin group recorded a reduction of only 63% in the seroma fluid volume. The NPs exerted local anti-inflammatory and neo-angiogenic effects, without any detectable systemic changes. Moreover, the ceria levels recorded in the organs did not surpass the background level, indicating that the nanoparticles stayed at the site of application. This study is a promising first example demonstrating the ability of inorganic nanoparticle formulations to reduce seroma formation in a rat model, without any detectable systemic adverse effects. These results emphasize the potential of nanotechnological solutions in the therapeutic management of seroma in the clinical setting.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
American Chemical Society
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Seroma
en_US
dc.subject
Mixed metal oxide nanoparticles
en_US
dc.subject
Animal model
en_US
dc.title
Mixed Metal Oxide Nanoparticle Formulations for the Treatment of Seroma
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2021-04-23
ethz.journal.title
ACS Biomaterials Science & Engineering
ethz.journal.volume
7
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
ACS Biomater. Sci. Eng.
ethz.pages.start
2676
en_US
ethz.pages.end
2686
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Integrative Engineering of Metal Oxide Nanohybrid-based Surgical Adhesives: From Particle Design to Performance Assessment by Multiscale Analytics
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02668 - Inst. f. Energie- und Verfahrenstechnik / Inst. Energy and Process Engineering::09675 - Herrmann, Inge Katrin (ehemalig) / Herrmann, Inge Katrin (former)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02668 - Inst. f. Energie- und Verfahrenstechnik / Inst. Energy and Process Engineering::09675 - Herrmann, Inge Katrin (ehemalig) / Herrmann, Inge Katrin (former)
en_US
ethz.grant.agreementno
181290
ethz.grant.agreementno
181290
ethz.grant.agreementno
181290
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Eccellenza
ethz.grant.program
Eccellenza
ethz.grant.program
Eccellenza
ethz.date.deposited
2021-04-25T12:09:58Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-06-17T06:38:58Z
ethz.rosetta.lastUpdated
2024-02-02T14:08:01Z
ethz.rosetta.versionExported
true
ethz.COinS
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