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dc.contributor.author
Kouyos, Roger D.
dc.contributor.author
Leventhal, Gabriel E.
dc.contributor.author
Hinkley, Trevor
dc.contributor.author
Haddad, Mojgan
dc.contributor.author
Whitcomb, Jeanette M.
dc.contributor.author
Petropoulos, Christos J.
dc.contributor.author
Bonhoeffer, Sebastian
dc.date.accessioned
2018-11-05T09:34:56Z
dc.date.available
2017-06-09T23:37:57Z
dc.date.available
2018-11-05T09:34:56Z
dc.date.issued
2012-03-08
dc.identifier.issn
1553-7390
dc.identifier.issn
1553-7404
dc.identifier.other
10.1371/journal.pgen.1002551
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/48517
dc.identifier.doi
10.3929/ethz-b-000048517
dc.description.abstract
Although fitness landscapes are central to evolutionary theory, so far no biologically realistic examples for large-scale fitness landscapes have been described. Most currently available biological examples are restricted to very few loci or alleles and therefore do not capture the high dimensionality characteristic of real fitness landscapes. Here we analyze large-scale fitness landscapes that are based on predictive models for in vitro replicative fitness of HIV-1. We find that these landscapes are characterized by large correlation lengths, considerable neutrality, and high ruggedness and that these properties depend only weakly on whether fitness is measured in the absence or presence of different antiretrovirals. Accordingly, adaptive processes on these landscapes depend sensitively on the initial conditions. While the relative extent to which mutations affect fitness on their own (main effects) or in combination with other mutations (epistasis) is a strong determinant of these properties, the fitness landscape of HIV-1 is considerably less rugged, less neutral, and more correlated than expected from the distribution of main effects and epistatic interactions alone. Overall this study confirms theoretical conjectures about the complexity of biological fitness landscapes and the importance of the high dimensionality of the genetic space in which adaptation takes place.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science (PLoS)
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Exploring the Complexity of the HIV-1 Fitness Landscape
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS Genetics
ethz.journal.volume
8
en_US
ethz.journal.issue
3
en_US
ethz.journal.abbreviated
PLoS Genet
ethz.pages.start
e1002551
en_US
ethz.size
9 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
005410305
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
ethz.date.deposited
2017-06-09T23:39:17Z
ethz.source
ECIT
ethz.identifier.importid
imp59364f2b5c98c48490
ethz.ecitpid
pub:79816
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-19T10:00:17Z
ethz.rosetta.lastUpdated
2018-11-05T09:35:10Z
ethz.rosetta.versionExported
true
ethz.COinS
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