Show simple item record

dc.contributor.author
Mannucci, Silvia
dc.contributor.author
Tambalo, Stefano
dc.contributor.author
Conti, Giamaica
dc.contributor.author
Ghin, Leonardo
dc.contributor.author
Milanese, Alessio
dc.contributor.author
Carboncino, Anna
dc.contributor.author
Nicolato, Elena
dc.contributor.author
Marinozzi, Maria Rosaria
dc.contributor.author
Benati, Donatella
dc.contributor.author
Bassi, Roberto
dc.contributor.author
Marzola, Pasquina
dc.contributor.author
Sbarbati, Andrea
dc.date.accessioned
2021-06-09T14:49:23Z
dc.date.available
2021-06-09T09:11:53Z
dc.date.available
2021-06-09T14:49:23Z
dc.date.issued
2018-07-11
dc.identifier.issn
1555-4317
dc.identifier.issn
1555-4309
dc.identifier.other
10.1155/2018/2198703
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/488962
dc.identifier.doi
10.3929/ethz-b-000488962
dc.description.abstract
Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacteria: magnetosomes. The efficacy of such protocol is tested in a xenograft model of glioblastoma. Mice receive a single intratumoral injection of magnetosomes, and they are exposed three times in a week to an alternating magnetic field with concurrent temperature measurements. MRI is used to visualize the nanoparticles and to monitor tumor size before and after the treatment. Statistically significant inhibition of the tumor growth is detected in subjects exposed to the alternating magnetic field compared to control groups. Moreover, thanks to magnetosomes high transversal relaxivity, their effective delivery to the tumor tissue is monitored by MRI. It is apparent that the efficacy of this protocol is limited by inhomogeneous delivery of magnetosomes to tumor tissue. These results suggest that naturally synthesized magnetosomes could be effectively considered as theranostic agent candidates for hyperthermia based on iron oxide nanoparticles.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Hindawi
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Magnetosomes Extracted from Magnetospirillum gryphiswaldense as Theranostic Agents in an Experimental Model of Glioblastoma.
en_US
dc.type
Journal Article
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Contrast Media & Molecular Imaging
ethz.journal.volume
2018
en_US
ethz.journal.abbreviated
Contrast Media Mol Imaging
ethz.pages.start
2198703
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.pubmed
30116160
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::09583 - Sunagawa, Shinichi / Sunagawa, Shinichi
en_US
ethz.identifier.orcidWorkCode
83697097
ethz.identifier.url
https://europepmc.org/articles/PMC6079595
ethz.date.deposited
2021-06-09T09:11:59Z
ethz.source
FORM
ethz.eth
no
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-06-09T14:49:29Z
ethz.rosetta.lastUpdated
2022-03-29T08:43:04Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Magnetosomes%20Extracted%20from%20Magnetospirillum%20gryphiswaldense%20as%20Theranostic%20Agents%20in%20an%20Experimental%20Model%20of%20Glioblastoma.&rft.jtitle=Contrast%20Media%20&%20Molecular%20Imaging&rft.date=2018-07-11&rft.volume=2018&rft.spage=2198703&rft.issn=1555-4317&1555-4309&rft.au=Mannucci,%20Silvia&Tambalo,%20Stefano&Conti,%20Giamaica&Ghin,%20Leonardo&Milanese,%20Alessio&rft.genre=article&article&rft_id=info:doi/10.1155/2018/2198703&
 Search print copy at ETH Library

Files in this item

Thumbnail

Publication type

Show simple item record