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dc.contributor.author
Gajdos, Viktor
dc.contributor.supervisor
Krayenbühl, Jérôme
dc.date.accessioned
2021-06-16T09:04:57Z
dc.date.available
2021-06-16T08:28:33Z
dc.date.available
2021-06-16T09:04:57Z
dc.date.issued
2020-10
dc.identifier.uri
http://hdl.handle.net/20.500.11850/489836
dc.identifier.doi
10.3929/ethz-b-000489836
dc.description.abstract
Total Body Irradiation (TBI) is a type of Radiation Therapy (RT) technique, used for irradiation of the whole patient body. The standard way of TBI is based on static photon beams with more than 3 m long distance between the radiation source and the patient. But it is often not possible in smaller size radiation therapy rooms in many RT centers. Modulated Arc (mARC) technique for TBI, is one of the techniques to perform TBI with a standard linear accelerator in smaller size RT rooms and does not require special equipment. Commercial treatment planning systems (TPS) for RT, at least Varian Eclipse® used in University Hospital Zurich (USZ), do not offer a dedicated planning option for ARC mode TBI. In this work, a new calculation method for mARC parameters has been developed. It is based on an optimization algorithm from Python 3 library SciPy, calculating the ratio of field weights in mARC, which leads to optimized dose distribution in the patient. Optimization can be customized according to the size of the patient and required dose homogeneity. The method was tested on virtual water phantoms mARC planning in TPS and with confirmative measurement on the linear accelerator with long solid water slab phantom. An example of the treatment plan in mARC mode was prepared and evaluated using CTs of one real TBI patient. The proposed mARC method performed well in the preliminary evaluations, and we can recommend it to be considered for clinical use in TBI therapy in USZ.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
ETH Zurich
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.subject
total body irradiation
en_US
dc.subject
tbi
en_US
dc.subject
modulated arc
en_US
dc.subject
radiotherapy
en_US
dc.title
Development and evaluation of modulated arc technique for total body irradiation radiotherapy
en_US
dc.type
Master Thesis
dc.rights.license
In Copyright - Non-Commercial Use Permitted
ethz.size
43 p.
en_US
ethz.code.ddc
DDC - DDC::5 - Science::530 - Physics
en_US
ethz.code.jel
::JEL - JEL::I - Health, Education, and Welfare
en_US
ethz.publication.place
Zurich
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering
en_US
ethz.tag
Python
en_US
ethz.tag
Optimization
en_US
ethz.tag
objective function
en_US
ethz.date.deposited
2021-06-16T08:28:39Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-06-16T09:05:04Z
ethz.rosetta.lastUpdated
2022-03-29T08:47:52Z
ethz.rosetta.versionExported
true
ethz.COinS
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