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dc.contributor.author
Ciotti, Federico
dc.contributor.author
Valle, Giacomo
dc.contributor.author
Pedrocchi, Alessandra
dc.contributor.author
Raspopovic, Stanisa
dc.date.accessioned
2021-06-17T06:13:12Z
dc.date.available
2021-06-17T02:49:49Z
dc.date.available
2021-06-17T06:13:12Z
dc.date.issued
2021
dc.identifier.isbn
978-1-7281-4337-8
en_US
dc.identifier.isbn
978-1-7281-4336-1
en_US
dc.identifier.isbn
978-1-7281-4338-5
en_US
dc.identifier.issn
19483554
dc.identifier.other
10.1109/NER49283.2021.9441309
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/490039
dc.description.abstract
A large population of both males and females is affected by sexual dysfunctions, while presently existing treatments have several drawbacks. Novel electroceutical approaches could be promising alternatives. Genital arousal is known to be controlled by autonomic and somatic activity. Most of the nerve fibers involved in these processes origin from the second to fourth sacral nerve, namely the efferent parasympathetic fibers and the afferent sensory fibers carrying the stimuli responsible of triggering reflex arousal, later forming the pudendal nerve. The latter is a reasonable target for implants since it follows a repeatable course and can be exposed via well-known surgical approaches. We compared existing implantable electrodes, the Interstim quadripolar lead and a multipolar cuff, in terms of thresholds and selectivity, which are the first requirement to deliver effective stimulation without inducing pain, spasms, or other collateral phenomena. We employed a hybrid modeling approach: the target nerve was 3D-modeled on real histological cross-sections. FEM modeling was performed to simulate current injection into the fascicles. The fascicles were then populated with compartmentalized axons and neurophysiological simulations using the MRG model were performed. We estimated whether, and at which injected charge level, each axon fired along its length and computed parameters of interest, resulting in hints to guide the development of a future bioelectronic solution.
en_US
dc.language.iso
en
en_US
dc.publisher
IEEE
en_US
dc.subject
Computational Neural modeling
en_US
dc.subject
Sexual Dysfunction
en_US
dc.subject
Bioelectronics
en_US
dc.subject
Neural implants
en_US
dc.title
A Computational Model of the Pudendal Nerve for the Bioelectronic Treatment of Sexual Dysfunctions
en_US
dc.type
Conference Paper
dc.date.published
2021-06-02
ethz.book.title
2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)
en_US
ethz.pages.start
267
en_US
ethz.pages.end
270
en_US
ethz.event
10th International IEEE/EMBS Conference on Neural Engineering (NER 2021)
en_US
ethz.event.location
Online
en_US
ethz.event.date
May 4-6, 2021
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Piscataway, NJ
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-06-17T02:50:03Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-06-17T06:13:18Z
ethz.rosetta.lastUpdated
2022-03-29T08:49:43Z
ethz.rosetta.versionExported
true
ethz.COinS
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