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dc.contributor.author
Adamo, Giorgia
dc.contributor.author
Fierli, David
dc.contributor.author
Romancino, Daniele P.
dc.contributor.author
Picciotto, Sabrina
dc.contributor.author
Barone, Maria E.
dc.contributor.author
Aranyos, Anita
dc.contributor.author
Božič, Darja
dc.contributor.author
Morsbach, Svenja
dc.contributor.author
Raccosta, Samuele
dc.contributor.author
Stanly, Christopher
dc.contributor.author
Paganini, Carolina
dc.contributor.author
Gai, Meiyu
dc.contributor.author
Cusimano, Antonella
dc.contributor.author
Martorana, Vincenzo
dc.contributor.author
Noto, Rosina
dc.contributor.author
Carrotta, Rita
dc.contributor.author
Librizzi, Fabio
dc.contributor.author
Randazzo, Loredana
dc.contributor.author
Parkes, Rachel
dc.contributor.author
Capasso Palmiero, Umberto
dc.contributor.author
Rao, Estella
dc.contributor.author
Paterna, Angela
dc.contributor.author
Santonicola, Pamela
dc.contributor.author
Iglič, Ales
dc.contributor.author
Corcuera, Laura
dc.contributor.author
Kisslinger, Annamaria
dc.contributor.author
Di Schiavi, Elia
dc.contributor.author
Liguori, Giovanna L.
dc.contributor.author
Landfester, Katharina
dc.contributor.author
Kralj-Iglič, Veronika
dc.contributor.author
Arosio, Paolo
dc.contributor.author
Pocsfalvi, Gabriella
dc.contributor.author
Touzet, Nicolas
dc.contributor.author
Manno, Mauro
dc.contributor.author
Bongiovanni, Antonella
dc.date.accessioned
2021-07-08T09:10:13Z
dc.date.available
2021-06-21T03:08:43Z
dc.date.available
2021-07-08T09:10:13Z
dc.date.issued
2021-04
dc.identifier.issn
2001-3078
dc.identifier.other
10.1002/jev2.12081
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/490460
dc.identifier.doi
10.3929/ethz-b-000490460
dc.description.abstract
Cellular, inter-organismal and cross kingdom communication via extracellular vesicles (EVs) is intensively studied in basic science with high expectation for a large variety of bio-technological applications. EVs intrinsically possess many attributes of a drug delivery vehicle. Beyond the implications for basic cell biology, academic and industrial interests in EVs have increased in the last few years. Microalgae constitute sustainable and renewable sources of bioactive compounds with a range of sectoral applications, including the formulation of health supplements, cosmetic products and food ingredients. Here we describe a newly discovered subtype of EVs derived from microalgae, which we named nanoalgosomes. We isolated these extracellular nano-objects from cultures of microalgal strains, including the marine photosynthetic chlorophyte Tetraselmis chuii, using differential ultracentrifugation or tangential flow fractionation and focusing on the nanosized small EVs (sEVs). We explore different biochemical and physical properties and we show that nanoalgosomes are efficiently taken up by mammalian cell lines, confirming the cross kingdom communication potential of EVs. This is the first detailed description of such membranous nanovesicles from microalgae. With respect to EVs isolated from other organisms, nanoalgosomes present several advantages in that microalgae are a renewable and sustainable natural source, which could easily be scalable in terms of nanoalgosome production.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Biogenic nano-delivery system
en_US
dc.subject
EV-based therapeutics
en_US
dc.subject
Extracellular vesicles of non-mammalian organ-isms
en_US
dc.subject
Microalgae
en_US
dc.subject
Microalgal extracellular vesicles
en_US
dc.subject
Nanoalgosomes
en_US
dc.title
Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2021-04-27
ethz.journal.title
Journal of Extracellular Vesicles
ethz.journal.volume
10
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
j Extracell Vesicles
ethz.pages.start
e12081
en_US
ethz.size
22 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Extracellular vesicles from a natural source for tailor-made nanomaterials
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::09572 - Arosio, Paolo / Arosio, Paolo
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::09572 - Arosio, Paolo / Arosio, Paolo
ethz.grant.agreementno
801338
ethz.grant.fundername
EC
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.program
H2020
ethz.date.deposited
2021-06-21T03:08:48Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-07-08T09:10:27Z
ethz.rosetta.lastUpdated
2024-02-02T14:16:58Z
ethz.rosetta.versionExported
true
ethz.COinS
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