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Date
2021-06-22Type
- Review Article
Citations
Cited 14 times in
Web of Science
Cited 17 times in
Scopus
ETH Bibliography
yes
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Abstract
The perception of adipose tissue, both in the scientific community and in the general population, has changed dramatically in the past 20 years. While adipose tissue was thought for a long time to be a rather simple lipid storage entity, it is now recognized as a highly heterogeneous organ and a critical regulator of systemic metabolism, composed of many different subtypes of cells, with important endocrine functions. Additionally, adipose tissue is nowadays recognized to contribute to energy turnover, due to the presence of specialized thermogenic adipocytes, which can be found in many adipose depots. This review discusses the unprecedented insights that we have gained into the heterogeneity of thermogenic adipocytes and their respective precursors due to the technical developments in single-cell and nucleus technologies. These methodological advances have increased our understanding of how adipose tissue catabolic function is influenced by developmental and intercellular communication events. Show more
Publication status
publishedExternal links
Journal / series
Nature MetabolismVolume
Pages / Article No.
Publisher
NatureSubject
Cardiovascular biology; Cell signalling; Fat metabolismOrganisational unit
03819 - Wolfrum, Christian / Wolfrum, Christian
Funding
185011 - Adipose tissue heterogeneity and metabolic control (SNF)
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Show all metadata
Citations
Cited 14 times in
Web of Science
Cited 17 times in
Scopus
ETH Bibliography
yes
Altmetrics