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dc.contributor.author
Pohlmeier, Lea
dc.contributor.author
Sonar, Sanchaita S.
dc.contributor.author
Rodewald, Hans-Reimer
dc.contributor.author
Kopf, Manfred
dc.contributor.author
Tortola, Luigi
dc.date.accessioned
2021-07-05T14:29:05Z
dc.date.available
2021-07-04T03:19:11Z
dc.date.available
2021-07-05T14:29:05Z
dc.date.issued
2021-07
dc.identifier.issn
0105-4538
dc.identifier.issn
1398-9995
dc.identifier.other
10.1111/all.14765
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/492889
dc.description.abstract
Background Asthma is a frequent chronic disease that can potentially severely affect the respiratory capacity and well-being of patients. Mast cells (MCs) are regarded as major players in human asthma due to their capacity to release crucial inflammatory mediators following allergen exposure. However, unambiguous characterization of their role in animal models has long been hindered by the unavailability of specific MC-deficient models lacking confounding MC-unrelated effects. This study aims to examine the role of MCs in Kit-sufficient MC-deficient Cpa3Cre/+ mice. Methods We used a variety of models of acute and chronic asthma employing distinct routes and regimes of sensitization. These sensitizations were done via the peritoneal cavity, the skin, or the lung. Additionally, different allergens, i.e. ovalbumin and house dust mite extract, were used. Results Our results show that the absence of MCs had no impact on the severity of allergic airway inflammation in any of the tested mouse models, as measured by leukocyte infiltration in the airways, cytokine expression, antibody production, airway hyper-responsiveness and mucus production. Conclusion This indicates that MCs do not play a major role in murine allergic airway inflammation.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
allergic airway inflammation
en_US
dc.subject
asthma models
en_US
dc.subject
Kit-sufficient
en_US
dc.subject
mast cells
en_US
dc.title
Comparative analysis of the role of mast cells in murine asthma models using Kit-sufficient mast cell-deficient animals
en_US
dc.type
Journal Article
dc.date.published
2021-02-09
ethz.journal.title
Allergy
ethz.journal.volume
76
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
Allergy (Cph.)
ethz.pages.start
2030
en_US
ethz.pages.end
2043
en_US
ethz.grant
Identification of PPARg target genes in macrophages and characterization of their functional roles
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Chichester
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03596 - Kopf, Manfred / Kopf, Manfred
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03596 - Kopf, Manfred / Kopf, Manfred
ethz.grant.agreementno
182829
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Exzellenzbeitrag in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2021-07-04T03:19:14Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-07-05T14:29:12Z
ethz.rosetta.lastUpdated
2021-07-05T14:29:12Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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