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dc.contributor.author
Boos, Julia A.
dc.contributor.author
Misun, Patrick
dc.contributor.author
Brunoldi, Giulia
dc.contributor.author
Furer, Lea A.
dc.contributor.author
Aengenheister, Leonie
dc.contributor.author
Modena, Mario
dc.contributor.author
Rousset, Nassim
dc.contributor.author
Buerki-Thurnherr, Tina
dc.contributor.author
Hierlemann, Andreas
dc.date.accessioned
2021-09-14T06:37:35Z
dc.date.available
2021-07-06T04:02:51Z
dc.date.available
2021-07-13T12:26:42Z
dc.date.available
2021-09-01T12:25:11Z
dc.date.available
2021-09-07T11:35:01Z
dc.date.available
2021-09-14T06:37:35Z
dc.date.issued
2021-08
dc.identifier.issn
2701-0198
dc.identifier.other
10.1002/adbi.202100609
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/493174
dc.identifier.doi
10.3929/ethz-b-000493174
dc.description.abstract
Safety assessment of the effects of developmental toxicants on pregnant women is challenging, and systemic effects in embryo–maternal interactions are largely unknown. However, most developmental toxicity studies rely on animal trials, while in vitro platforms that recapitulate the maternal–placental–embryonic axis are missing. Here, the development of a dedicated microfluidic device for co-cultivation of a placental barrier and 3D embryoid bodies to enable systemic toxicity testing at the embryo–maternal interface is reported. The microfluidic platform features simple handling and recuperation of both tissue models, which facilitates post-hoc in-depth analysis at the tissue and single-cell level. Gravity-driven flow enables inter-tissue communication through the liquid phase as well as simple and robust operation and renders the platform parallelizable. As a proof of concept and to demonstrate platform use for systemic embryotoxicity testing in vitro, maternal exposure to plastic microparticles is emulated, and microparticle effects on the embryo–placental co-culture are investigated.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley-VCH
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
3D microtissues
en_US
dc.subject
developmental toxicity
en_US
dc.subject
embryoid bodies
en_US
dc.subject
hanging drops
en_US
dc.subject
microfluidics
en_US
dc.subject
placenta
en_US
dc.title
Microfluidic Co-Culture Platform to Recapitulate the Maternal–Placental–Embryonic Axis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2021-06-19
ethz.journal.title
Advanced Biology
ethz.journal.volume
5
en_US
ethz.journal.issue
8
en_US
ethz.journal.abbreviated
Adv. Biology
ethz.pages.start
2100609
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Miccrofluidic Multi-tissue Platform for Systemic Embryotoxicity Testing
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.grant.agreementno
ETH-11 16-1 METAEST
ethz.grant.fundername
ETHZ
ethz.grant.funderDoi
10.13039/501100003006
ethz.grant.program
ETH Grants
ethz.date.deposited
2021-07-06T04:03:09Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-09-01T12:25:18Z
ethz.rosetta.lastUpdated
2022-03-29T11:32:32Z
ethz.rosetta.versionExported
true
ethz.COinS
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