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dc.contributor.author
Forrer, Anja
dc.contributor.author
Schoenrath, Felix
dc.contributor.author
Torzewski, Michael
dc.contributor.author
Schmid, Jens
dc.contributor.author
Franke, Urlich F.W.
dc.contributor.author
Göbel, Nora
dc.contributor.author
Aujesky, Drahomir
dc.contributor.author
Matter, Christian M.
dc.contributor.author
Lüscher, Thomas F.
dc.contributor.author
Mach, Francois
dc.contributor.author
Nanchen, David
dc.contributor.author
Rodondi, Nicolas
dc.contributor.author
Falk, Volkmar
dc.contributor.author
von Eckardstein, Arnold
dc.contributor.author
Gawinecka, Joanna
dc.date.accessioned
2021-08-13T13:59:11Z
dc.date.available
2021-07-10T05:19:54Z
dc.date.available
2021-08-13T13:59:11Z
dc.date.issued
2021-04
dc.identifier.issn
2075-4418
dc.identifier.other
10.3390/diagnostics11040615
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/493852
dc.identifier.doi
10.3929/ethz-b-000493852
dc.description.abstract
Acute aortic dissection (AAD) is a rare condition, but together with acute myocardial infarction (AMI) and pulmonary embolism (PE) it belongs to the most relevant and life-threatening causes of acute chest pain. Until now, there has been no specific blood test in the diagnostic workup of AAD. To identify clinically relevant biomarkers for AAD, we applied Proseek® Multiplex assays to plasma samples from patients with AAD, AMI, PE, thoracic aortic aneurysm (TAA), and non-cardiovascular chest pain (nonCVD). Subsequently, we validated top hits using conventional immunoassays and examined their expression in the aortic tissue. Interleukin 10 (IL-10) alone showed the best performance with a sensitivity of 55% and a specificity of 98% for AAD diagnosis. The combination of D-dimers, high-sensitive troponin T (hs-TnT), interleukin 6 (IL-6), and plasminogen activator inhibitor 1 (PAI1) correctly classified 75% of AAD cases, delivering a sensitivity of 83% and specificity of 95% for its diagnosis. Moreover, this model provided the correct classification of 77% of all analyzed cases. Our data suggest that IL-10 shows potential to be a rule-in biomarker for AAD. Moreover, the addition of PAI1 and IL-6 to hs-TnT and D-dimers may improve the discrimination of suspected AAD, AMI, and PE in patients presenting with acute chest pain.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
acute aortic dissection
en_US
dc.subject
biomarker
en_US
dc.subject
D-dimers
en_US
dc.subject
Pulmonary embolism
en_US
dc.subject
Acute myocardial infarction
en_US
dc.subject
IL-10
en_US
dc.title
Novel blood biomarkers for a diagnostic workup of acute aortic dissection
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Diagnostics
ethz.journal.volume
11
en_US
ethz.journal.issue
4
en_US
ethz.pages.start
615
en_US
ethz.size
15 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02540 - Institut für Translationale Medizin / Institute of Translational Medicine::09667 - Falk, Volkmar / Falk, Volkmar
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02540 - Institut für Translationale Medizin / Institute of Translational Medicine::09667 - Falk, Volkmar / Falk, Volkmar
ethz.date.deposited
2021-07-10T05:20:06Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-08-13T13:59:17Z
ethz.rosetta.lastUpdated
2024-02-02T14:31:41Z
ethz.rosetta.versionExported
true
ethz.COinS
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