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dc.contributor.author
Vertti-Quintero, Nadia
dc.contributor.author
Berger, Simon
dc.contributor.author
Casadevall i Solvas, Xavier
dc.contributor.author
Statzer, Cyril
dc.contributor.author
Annis, Jillian
dc.contributor.author
Ruppen, Peter
dc.contributor.author
Stavrakis, Stavros
dc.contributor.author
Ewald, Collin
dc.contributor.author
Gunawan, Rudiyanto
dc.contributor.author
de Mello, Andrew
dc.date.accessioned
2021-07-29T13:23:23Z
dc.date.available
2021-07-13T02:27:08Z
dc.date.available
2021-07-13T05:58:49Z
dc.date.available
2021-07-29T13:23:23Z
dc.date.issued
2021-07-28
dc.identifier.issn
1613-6810
dc.identifier.issn
1613-6829
dc.identifier.other
10.1002/smll.202102145
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/494188
dc.identifier.doi
10.3929/ethz-b-000494188
dc.description.abstract
Significant non-genetic stochastic factors affect aging, causing lifespan differences among individuals, even those sharing the same genetic and environmental background. In Caenorhabditis elegans, differences in heat-shock response (HSR) are predictive of lifespan. However, factors contributing to the heterogeneity of HSR are still not fully elucidated. Here, the authors characterized HSR dynamics in isogenic C. elegans expressing GFP reporter for hsp-16.2 for identifying the key contributors of HSR heterogeneity. Specifically, microfluidic devices that enable cross-sectional and longitudinal measurements of HSR dynamics in C. elegans at different scales are developed: in populations, within individuals, and in embryos. The authors adapted a mathematical model of HSR to single C. elegans and identified model parameters associated with proteostasis—maintenance of protein homeostasis—more specifically, protein turnover, as the major drivers of heterogeneity in HSR dynamics. It is verified that individuals with enhanced proteostasis fidelity in early adulthood live longer. The model-based comparative analysis of protein turnover in day-1 and day-2 adult C. elegans revealed a stochastic-onset of age-related proteostasis decline that increases the heterogeneity of HSR capacity. Finally, the analysis of C. elegans embryos showed higher HSR and proteostasis capacity than young adults and established transgenerational contribution to HSR heterogeneity that depends on maternal age.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
aging
en_US
dc.subject
C. elegans
en_US
dc.subject
heat-shock response
en_US
dc.subject
heterogeneity
en_US
dc.subject
microfluidics
en_US
dc.subject
proteostasis
en_US
dc.title
Stochastic and Age-Dependent Proteostasis Decline Underlies Heterogeneity in Heat-Shock Response Dynamics
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2021-07-01
ethz.journal.title
Small
ethz.journal.volume
17
en_US
ethz.journal.issue
30
en_US
ethz.pages.start
2102145
en_US
ethz.size
22 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
The role of extracellular matrix enhancement in promoting healthy aging
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03914 - deMello, Andrew / deMello, Andrew
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03914 - deMello, Andrew / deMello, Andrew
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02540 - Institut für Translationale Medizin / Institute of Translational Medicine::09598 - Ewald, Collin Y. / Ewald, Collin Y.
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03914 - deMello, Andrew / deMello, Andrew
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02540 - Institut für Translationale Medizin / Institute of Translational Medicine::09598 - Ewald, Collin Y. / Ewald, Collin Y.
ethz.grant.agreementno
163898
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
SNF-Förderungsprofessuren Stufe 2
ethz.date.deposited
2021-07-13T02:27:24Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-07-29T13:23:29Z
ethz.rosetta.lastUpdated
2022-03-29T10:48:48Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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