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dc.contributor.author
Bala, Fouzi
dc.contributor.author
Ospel, Johanna
dc.contributor.author
Mulpur, Bhageeradh
dc.contributor.author
Kim, Beom J.
dc.contributor.author
Yoo, Joon Sang
dc.contributor.author
Menon, Bijoy K.
dc.contributor.author
Goyal, Mayank
dc.contributor.author
Federau, Christian
dc.contributor.author
Sohn, Sung-Il
dc.contributor.author
Hussain, Muhammad Shazam
dc.contributor.author
Almekhlafi, Mohammed A.
dc.date.accessioned
2021-08-17T09:14:55Z
dc.date.available
2021-07-15T10:19:00Z
dc.date.available
2021-07-21T07:04:30Z
dc.date.available
2021-08-17T09:14:55Z
dc.date.issued
2021-08
dc.identifier.issn
0195-6108
dc.identifier.other
10.3174/ajnr.A7177
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/494782
dc.description.abstract
BACKGROUND: Infarct volume inversely correlates with good recovery in stroke. The magnitude and predictors of infarct growth despite successful reperfusion via endovascular treatment are not known. PURPOSE: We aimed to summarize the extent of infarct growth in patients with acute stroke who achieved successful reperfusion (TICI 2b–3) after endovascular treatment. DATA SOURCES: We performed a systematic review and meta-analysis by searching MEDLINE and Google Scholar for articles published up to October 31, 2020. STUDY SELECTION: Studies of >10 patients reporting baseline and post-endovascular treatment infarct volumes on MR imaging were included. Only patients with TICI 2b–3 were included. We calculated infarct growth at a study level as the difference between baseline and follow-up MR imaging infarct volumes. DATA ANALYSIS: Our search yielded 345 studies, and we included 10 studies reporting on 973 patients having undergone endovascular treatment who achieved successful reperfusion. DATA SYNTHESIS: The mean baseline infarct volume was 19.5 mL, while the mean final infarct volume was 37.5 mL. A TICI 2b reperfusion grade was achieved in 24% of patients, and TICI 2c or 3 in 76%. The pooled mean infarct growth was 14.8 mL (95% CI, 7.9–21.7 mL). Meta-regression showed higher infarct growth in studies that reported higher baseline infarct volumes, higher rates of incomplete reperfusion (modified TICI 2b), and longer onset-to-reperfusion times. LIMITATIONS: Significant heterogeneity among studies was noted and might be driven by the difference in infarct growth between early- and late-treatment studies. CONCLUSIONS: These results suggest considerable infarct growth despite successful endovascular treatment reperfusion and call for a faster workflow and the need for specific therapies to limit infarct growth.
en_US
dc.language.iso
en
en_US
dc.publisher
American Society of Neuroradiology
en_US
dc.title
Infarct Growth despite Successful Endovascular Reperfusion in Acute Ischemic Stroke: A Meta-analysis
en_US
dc.type
Journal Article
dc.date.published
2021-06-03
ethz.journal.title
American Journal of Neuroradiology
ethz.journal.volume
42
en_US
ethz.journal.issue
8
en_US
ethz.journal.abbreviated
Am J Neuroradiol
ethz.pages.start
1472
en_US
ethz.pages.end
1478
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oak Brook, IL
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-07-15T10:20:12Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-08-17T09:15:01Z
ethz.rosetta.lastUpdated
2021-08-17T09:15:01Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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