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Reactive oxygen species (ROS) were long considered unwanted and dangerous by-products of mitochondrial metabolism, specifically oxidative phosphorylation. More recently, evidence has indicated that mitochondrial ROS are also essential signalling molecules that unexpectedly promote longevity, through a mechanism termed mitohormesis. In this issue, Timblin et al. expand this concept to immunity, specifically macrophage function, by demonstrating that mitochondrial ROS are required to prevent an excessive immune response. Show more
Journal / seriesNature Metabolism
Pages / Article No.
PublisherNature Publishing Group
SubjectAcute inflammation; Metabolism; Mitochondria; Monocytes and macrophages
Organisational unit03976 - Ristow, Michael / Ristow, Michael
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