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dc.contributor.author
Fournier, Elora
dc.contributor.author
Roussel, Charlène
dc.contributor.author
Dominicis, Alessandra
dc.contributor.author
Ley, Delphine
dc.contributor.author
Peyron, Marie-Agnès
dc.contributor.author
Collado, Valérie
dc.contributor.author
Mercier-Bonin, Muriel
dc.contributor.author
Lacroix, Christophe
dc.contributor.author
Alric, Monique
dc.contributor.author
Van de Wiele, Tom
dc.contributor.author
Chassard, Christophe
dc.contributor.author
Etienne-Mesmin, Lucie
dc.contributor.author
Blanquet-Diot, Stéphanie
dc.date.accessioned
2022-01-14T13:02:15Z
dc.date.available
2021-07-22T14:07:05Z
dc.date.available
2021-07-27T06:58:52Z
dc.date.available
2022-01-14T13:02:15Z
dc.date.issued
2022-01
dc.identifier.issn
0734-9750
dc.identifier.issn
1873-1899
dc.identifier.other
10.1016/j.biotechadv.2021.107796
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/497121
dc.description.abstract
The human digestion is a multi-step and multi-compartment process essential for human health, at the heart of many issues raised by academics, the medical world and industrials from the food, nutrition and pharma fields. In the first years of life, major dietary changes occur and are concomitant with an evolution of the whole child digestive tract anatomy and physiology, including colonization of gut microbiota. All these phenomena are influenced by child exposure to environmental compounds, such as drugs (especially antibiotics) and food pollutants, but also childhood infections. Due to obvious ethical, regulatory and technical limitations, in vivo approaches in animal and human are more and more restricted to favor complementary in vitro approaches. This review summarizes current knowledge on the evolution of child gut physiology from birth to 3 years old regarding physicochemical, mechanical and microbial parameters. Then, all the available in vitro models of the child digestive tract are described, ranging from the simplest static mono-compartmental systems to the most sophisticated dynamic and multi-compartmental models, and mimicking from the oral phase to the colon compartment. Lastly, we detail the main applications of child gut models in nutritional, pharmaceutical and microbiological studies and discuss the limitations and challenges facing this field of research.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Child
en_US
dc.subject
Digestion
en_US
dc.subject
Gut physiology evolution
en_US
dc.subject
Gut microbiota
en_US
dc.subject
In vitro gut models
en_US
dc.subject
Nutrition
en_US
dc.subject
Pharmacy
en_US
dc.subject
Microbiology
en_US
dc.subject
Toxicology
en_US
dc.title
In vitro models of gut digestion across childhood: current developments, challenges and future trends
en_US
dc.type
Review Article
dc.date.published
2021-07-09
ethz.journal.title
Biotechnology Advances
ethz.journal.volume
54
en_US
ethz.journal.abbreviated
Biotech Advs
ethz.pages.start
107796
en_US
ethz.size
27 p.
en_US
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03626 - Lacroix, Christophe / Lacroix, Christophe
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03626 - Lacroix, Christophe / Lacroix, Christophe
en_US
ethz.date.deposited
2021-07-22T14:07:10Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2022-01-14T13:02:22Z
ethz.rosetta.lastUpdated
2022-01-14T13:02:22Z
ethz.rosetta.versionExported
true
ethz.COinS
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