Show simple item record

dc.contributor.author
Sanchez, Aurore
dc.contributor.author
Reginato, Giordano
dc.contributor.author
Cejka, Petr
dc.date.accessioned
2021-07-30T16:11:13Z
dc.date.available
2021-07-30T02:43:30Z
dc.date.available
2021-07-30T16:11:13Z
dc.date.issued
2021-12
dc.identifier.issn
0959-437X
dc.identifier.issn
1879-0380
dc.identifier.other
10.1016/j.gde.2021.06.012
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/498490
dc.description.abstract
DNA breaks may arise accidentally in vegetative cells or in a programmed manner in meiosis. The usage of a DNA template makes homologous recombination potentially error-free, however, recombination is not always accurate. Cells possess a remarkable capacity to tailor processing of recombination intermediates to fulfill a particular need. Vegetatively growing cells aim to maintain genome stability and therefore repair accidental breaks largely accurately, using sister chromatids as templates, into mostly non-crossovers products. Recombination in meiotic cells is instead more likely to employ homologous chromosomes as templates and result in crossovers to allow proper chromosome segregation and promote genetic diversity. Here we review models explaining the processing of recombination intermediates in vegetative and meiotic cells and its regulation, with a focus on MLH1–MLH3-dependent crossing-over during meiotic recombination.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.title
Crossover or non-crossover outcomes: tailored processing of homologous recombination intermediates
en_US
dc.type
Review Article
ethz.journal.title
Current opinion in genetics & development
ethz.journal.volume
71
en_US
ethz.journal.abbreviated
Curr. opin. genet. dev.
ethz.pages.start
39
en_US
ethz.pages.end
47
en_US
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-07-30T02:43:34Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-07-30T16:11:21Z
ethz.rosetta.lastUpdated
2021-07-30T16:11:21Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Crossover%20or%20non-crossover%20outcomes:%20tailored%20processing%20of%20homologous%20recombination%20intermediates&rft.jtitle=Current%20opinion%20in%20genetics%20&%20development&rft.date=2021-12&rft.volume=71&rft.spage=39&rft.epage=47&rft.issn=0959-437X&1879-0380&rft.au=Sanchez,%20Aurore&Reginato,%20Giordano&Cejka,%20Petr&rft.genre=article&rft_id=info:doi/10.1016/j.gde.2021.06.012&
 Search print copy at ETH Library

Files in this item

FilesSizeFormatOpen in viewer

There are no files associated with this item.

Publication type

Show simple item record