Comparison of Psoriatic Arthritis and Rheumatoid Arthritis Patients across Body Mass Index Categories in Switzerland
dc.contributor.author
Vallejo-Yagüe, Enriqueta
dc.contributor.author
Burkard, Theresa
dc.contributor.author
Möller, Burkhard
dc.contributor.author
Finckh, Axel
dc.contributor.author
Burden, Andrea
dc.date.accessioned
2021-08-02T14:35:45Z
dc.date.available
2021-08-01T19:50:43Z
dc.date.available
2021-08-02T14:35:45Z
dc.date.issued
2021-07-02
dc.identifier.issn
2077-0383
dc.identifier.other
10.3390/jcm10143194
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/498827
dc.identifier.doi
10.3929/ethz-b-000498827
dc.description.abstract
Abnormal body mass index (BMI) was associated with worse rheumatic markers in psoriatic arthritis (PsA) and rheumatoid arthritis (RA). Aiming to describe PsA and RA patients stratified by BMI, we performed a descriptive study in PsA and RA patients (two distinct cohorts) in the Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) registry. New users of biologic or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) were stratified by BMI at the start of their treatment (underweight, normal weight, overweight, obese). The PsA underweight and normal weight categories were merged. Age at disease onset and further characteristics at the start of the first b/tsDMARD treatment were compared across BMI categories vs. the corresponding normal weight group. The study included 819 PsA (36.5% overweight, 23.8% obese) and 3217 RA patients (4.4% underweight, 31.8% overweight, 17.0% obese). Compared to the corresponding normal weight group, PsA and RA obese patients had significantly (p < 0.05) higher C-reactive protein, worse disease activity, and lower quality of life (QoL). Obese PsA patients had significantly worse skin manifestation and pain, while obese RA patients had significantly higher erythrocyte sedimentation rate and tender joint counts, as well as lower seropositive prevalence. To conclude, obese PsA and RA patients presented worse disease activity and poorer QoL than those with normal weight.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
psoriatic arthritis
en_US
dc.subject
rheumatoid arthritis
en_US
dc.subject
patient-reported outcomes
en_US
dc.subject
biologics
en_US
dc.title
Comparison of Psoriatic Arthritis and Rheumatoid Arthritis Patients across Body Mass Index Categories in Switzerland
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2021-07-20
ethz.journal.title
Journal of Clinical Medicine
ethz.journal.volume
10
en_US
ethz.journal.issue
14
en_US
ethz.journal.abbreviated
J Clin Med
ethz.pages.start
3194
en_US
ethz.size
19 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::09633 - Burden, Andrea / Burden, Andrea
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::09633 - Burden, Andrea / Burden, Andrea
ethz.date.deposited
2021-08-01T19:51:38Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-08-02T14:35:50Z
ethz.rosetta.lastUpdated
2025-02-13T23:52:31Z
ethz.rosetta.versionExported
true
ethz.COinS
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