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dc.contributor.author
Madhivanan, Purnima
dc.contributor.author
Krupp, Karl F.
dc.contributor.author
Coudray, Makella
dc.contributor.author
Colbert, Brett M.
dc.contributor.author
Ruiz-Perez, Daniel
dc.contributor.author
Cui, Haiyan
dc.contributor.author
Bokulich, Nicholas
dc.contributor.author
Narasimhan, Giri
dc.contributor.author
Mathee, Kalai
dc.contributor.author
Cook, Robert L.
dc.contributor.author
Schwebke, Jane
dc.contributor.author
Roe, Denise J.
dc.date.accessioned
2021-08-06T12:25:15Z
dc.date.available
2021-08-06T02:51:00Z
dc.date.available
2021-08-06T12:25:15Z
dc.date.issued
2021-08-09
dc.identifier.issn
0264-410X
dc.identifier.issn
1358-8745
dc.identifier.other
10.1016/j.vaccine.2021.07.026
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/499763
dc.description.abstract
Background: Chronic infection with high-risk human papillomavirus is a necessary cause for cervical carcinogenesis. This study examined prevalence of nonavalent vaccine preventable HPV types over four months among sexually active women in the United States. Methods: This sub-study obtained meta-data for 80 of the 1,365 women (18–25 years), enrolled in the BRAVO study, a randomized, open-label trial of home screening and treatment of asymptomatic bacterial vaginosis at high-risk for sexually transmitted infections conducted between 2008 and 2013. Participants were randomized to treatment or standard-of-care, and followed every 2-months for 12 months. Stored vaginal swabs from the first three visits were tested for the nine vaccine preventable HPV types using quantitative PCR. Prevalence and associated 95% confidence intervals for the HPV types were assessed using R (version 3.6.1). Results: The average age of the participants was 21.5 (SD ± 2.11) years, with 60% having ever been pregnant and all were African-American. Majority (71%) reported ≥ two sex partners in the prior year with 89% having unprotected vaginal sex and 45% having a new sex partner in the prior year. About 30% had ≥ one of the nine nonavalent vaccine HPV types at all three time points over a period of four months, 15% at two of any three visits, 19% at one of the three visits and 36% were negative for all nine vaccine HPV types at all time points. The most frequently detected HPV vaccine types were 52, 58, 16, and 18. The prevalence of any vaccine HPV types, and high-risk HPV types was 63.8% and 58.8%, respectively. Conclusions: Our findings suggest that HPV vaccination which is currently recommended for all unvaccinated persons through age 26 years, is likely to be more beneficial than previously thought as nonavalent HPV vaccine was not available during the time these data were collected.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Human papillomavirus
en_US
dc.subject
HPV Nonavalent vaccine
en_US
dc.subject
African-American
en_US
dc.subject
Women
en_US
dc.subject
Persistent infection
en_US
dc.subject
Revaccination
en_US
dc.title
Longitudinal assessment of nonavalent vaccine HPV types in a sample of sexually active African American women from ten U.S. Cities
en_US
dc.type
Journal Article
dc.date.published
2021-07-20
ethz.journal.title
Vaccine
ethz.journal.volume
39
en_US
ethz.journal.issue
34
en_US
ethz.journal.abbreviated
Vaccine
ethz.pages.start
4810
en_US
ethz.pages.end
4816
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::09714 - Bokulich, Nicholas / Bokulich, Nicholas
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::09714 - Bokulich, Nicholas / Bokulich, Nicholas
ethz.date.deposited
2021-08-06T02:51:04Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-08-06T12:25:22Z
ethz.rosetta.lastUpdated
2022-03-29T10:58:36Z
ethz.rosetta.versionExported
true
ethz.COinS
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