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dc.contributor.author
Landinez-Macias, Maria
dc.contributor.author
Qi, Weihong
dc.contributor.author
Bratus-Neuenschwander, Anna
dc.contributor.author
Müller, Martin
dc.contributor.author
Urwyler, Olivier
dc.date.accessioned
2021-10-25T15:17:14Z
dc.date.available
2021-09-22T02:58:50Z
dc.date.available
2021-10-25T15:17:14Z
dc.date.issued
2021-09-14
dc.identifier.issn
2666-3864
dc.identifier.issn
2211-1247
dc.identifier.other
10.1016/j.celrep.2021.109713
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/506364
dc.identifier.doi
10.3929/ethz-b-000506364
dc.description.abstract
Synaptic targeting with subcellular specificity is essential for neural circuit assembly. Developing neurons use mechanisms to curb promiscuous synaptic connections and to direct synapse formation to defined subcellular compartments. How this selectivity is achieved molecularly remains enigmatic. Here, we discover a link between mRNA poly(A)-tailing and axon collateral branch-specific synaptic connectivity within the CNS. We reveal that the RNA-binding protein Musashi binds to the mRNA encoding the receptor protein tyrosine phosphatase Ptp69D, thereby increasing poly(A) tail length and Ptp69D protein levels. This regulation specifically promotes synaptic connectivity in one axon collateral characterized by a high degree of arborization and strong synaptogenic potential. In a different compartment of the same axon, Musashi prevents ectopic synaptogenesis, revealing antagonistic, compartment-specific functions. Moreover, Musashi-dependent Ptp69D regulation controls synaptic connectivity in the olfactory circuit. Thus, Musashi differentially shapes synaptic connectivity at the level of individual subcellular compartments and within different developmental and neuron type-specific contexts.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Cell Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Synaptogenesis
en_US
dc.subject
axon collateral branch
en_US
dc.subject
CNS
en_US
dc.subject
Musashi
en_US
dc.subject
type IIa receptor protein tyrosine phosphatase
en_US
dc.subject
Ptp69D
en_US
dc.subject
post-transcriptional regulation
en_US
dc.subject
polyadenylation
en_US
dc.subject
TRIBE
en_US
dc.subject
RNA-binding protein
en_US
dc.title
The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2021-09-14
ethz.journal.title
Cell Reports
ethz.journal.volume
36
en_US
ethz.journal.issue
11
en_US
ethz.journal.abbreviated
Cell Rep
ethz.pages.start
109713
en_US
ethz.size
27 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Maryland Heights, MO
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.date.deposited
2021-09-22T02:59:14Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-10-25T15:17:25Z
ethz.rosetta.lastUpdated
2022-03-29T14:28:50Z
ethz.rosetta.versionExported
true
ethz.COinS
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