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dc.contributor.author
Martinez de la Torre, Adrian
dc.contributor.author
van Weenen, Eva
dc.contributor.author
Kraus, Mathias
dc.contributor.author
Weiler, Stefan
dc.contributor.author
Feuerriegel, Stefan
dc.contributor.author
Burden, Andrea
dc.date.accessioned
2021-10-14T18:49:03Z
dc.date.available
2021-10-09T02:59:57Z
dc.date.available
2021-10-14T18:49:03Z
dc.date.issued
2021-10
dc.identifier.issn
2077-0383
dc.identifier.other
10.3390/jcm10194486
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/508899
dc.identifier.doi
10.3929/ethz-b-000508899
dc.description.abstract
Acute generalized exanthematous pustulosis (AGEP) is a rare skin adverse drug reaction. The pathophysiology and causative drugs associated with AGEP are poorly understood, with the majority of studies in AGEP focusing on a single-drug-outcome association. We therefore aimed to explore and characterize frequently reported drug combinations associated with AGEP using the WHO pharmacovigilance database VigiBase. In this explorative cross-sectional study of a pharmacovigilance database using a data-driven approach, we assessed individual case safety reports (ICSR) with two or more drugs reported to VigiBase. A total of 2649 ICSRs reported two or more drugs. Cardiovascular drugs, including antithrombotics and beta-blockers, were frequently reported in combination with other drugs, particularly antibiotics. The drug pair of amoxicillin and furosemide was reported in 57 ICSRs (2.2%), with an O/E ratio of 1.3, and the combination of bisoprolol and furosemide was recorded 44 times (1.7%), with an O/E ratio of 5.5. The network analysis identified 10 different communities of varying sizes. The largest cluster primarily consisted of cardiovascular drugs. This data-driven and exploratory study provides the largest real-world assessment of drugs associated with AGEP to date. The results identify a high frequency of cardiovascular drugs, particularly used in combination with antibiotics.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
acute generalized exanthematous pustulos
en_US
dc.subject
AGEP
en_US
dc.subject
drug combination
en_US
dc.subject
network analysis
en_US
dc.title
A Network Analysis of Drug Combinations Associated with Acute Generalized Exanthematous Pustulosis (AGEP)
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2021-09-29
ethz.journal.title
Journal of Clinical Medicine
ethz.journal.volume
10
en_US
ethz.journal.issue
19
en_US
ethz.journal.abbreviated
J Clin Med
ethz.pages.start
4486
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02120 - Dep. Management, Technologie und Ökon. / Dep. of Management, Technology, and Ec.::09623 - Feuerriegel, Stefan (ehemalig) / Feuerriegel, Stefan (former)
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::09633 - Burden, Andrea / Burden, Andrea
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::09633 - Burden, Andrea / Burden, Andrea
ethz.relation.isCompiledBy
10.3929/ethz-b-000574473
ethz.date.deposited
2021-10-09T03:00:10Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-10-14T18:49:09Z
ethz.rosetta.lastUpdated
2023-02-06T22:41:18Z
ethz.rosetta.versionExported
true
ethz.COinS
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