Finger somatotopy is preserved after tetraplegia but deteriorates over time
dc.contributor.author
Kikkert, Sanne
dc.contributor.author
Pfyffer, Dario
dc.contributor.author
Verling, Michaela
dc.contributor.author
Freund, Patrick
dc.contributor.author
Wenderoth, Nicole
dc.date.accessioned
2021-11-09T09:45:07Z
dc.date.available
2021-11-05T08:14:44Z
dc.date.available
2021-11-09T09:45:07Z
dc.date.issued
2021
dc.identifier.issn
2050-084X
dc.identifier.other
10.7554/eLife.67713
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/513774
dc.identifier.doi
10.3929/ethz-b-000513774
dc.description.abstract
Previous studies showed reorganised and/or altered activity in the primary sensorimotor cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However, little is known about whether somatotopically specific representations can be activated despite reduced or absent afferent hand inputs. In this observational study, we used functional MRI and a (attempted) finger movement task in tetraplegic patients to characterise the somatotopic hand layout in primary somatosensory cortex. We further used structural MRI to assess spared spinal tissue bridges. We found that somatotopic hand representations can be activated through attempted finger movements in the absence of sensory and motor hand functioning, and no spared spinal tissue bridges. Such preserved hand somatotopy could be exploited by rehabilitation approaches that aim to establish new hand-brain functional connections after SCI (e.g. neuroprosthetics). However, over years since SCI the hand representation somatotopy deteriorated, suggesting that somatotopic hand representations are more easily targeted within the first years after SCI.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
eLife Sciences Publications
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Finger somatotopy is preserved after tetraplegia but deteriorates over time
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2021-10-19
ethz.journal.title
eLife
ethz.journal.volume
10
en_US
ethz.pages.start
e67713
en_US
ethz.size
26 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Non-invasive stimulation tools for modulating human brain function
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
ethz.grant.agreementno
175616
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projekte Lebenswissenschaften
ethz.date.deposited
2021-11-05T08:15:12Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-11-09T09:45:13Z
ethz.rosetta.lastUpdated
2024-02-02T15:20:11Z
ethz.rosetta.versionExported
true
ethz.COinS
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