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dc.contributor.author
Schlattner, Uwe
dc.contributor.author
Tokarska-Schlattner, Malgorzata
dc.contributor.author
Saudou, Frédéric
dc.contributor.author
Wallimann, Theo
dc.contributor.editor
Jez, Joseph
dc.date.accessioned
2021-11-17T14:03:01Z
dc.date.available
2021-11-13T08:08:08Z
dc.date.available
2021-11-17T14:03:01Z
dc.date.issued
2021
dc.identifier.isbn
978-0-12-822040-5
en_US
dc.identifier.other
10.1016/B978-0-12-819460-7.00336-4
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/515035
dc.description.abstract
Metabolite channeling is a general mechanism to increase efficiency of sequential reactions in a metabolic pathway. It describes the transfer of intermediates between sequential enzymes without equilibration of these metabolites with the surrounding bulk solution, forming so-called metabolons or microcompartments. It is structurally based on colocalization or complex formation of the participating enzymes and on specific diffusion limitations. In energy metabolism, metabolite channeling can maintain locally high and constant levels of “high energy phosphates” such as ATP or GTP, thus increasing the efficiency of the corresponding reactions. This involves enzymes like creatine kinase, nucleoside diphosphate kinase, or glycolytic enzymes.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.title
Regulation | Metabolite channeling in energy metabolism
en_US
dc.type
Encyclopedia Entry
dc.date.published
2021-08-02
ethz.book.title
Encyclopedia of Biological Chemistry III
en_US
ethz.journal.volume
1
en_US
ethz.pages.start
592
en_US
ethz.pages.end
598
en_US
ethz.version.edition
3rd edition
en_US
ethz.identifier.scopus
ethz.publication.place
San Diego, CA
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-11-13T08:08:22Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-11-17T14:03:08Z
ethz.rosetta.lastUpdated
2022-03-29T16:02:29Z
ethz.rosetta.versionExported
true
ethz.COinS
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