Show simple item record

dc.contributor.author
Yan, Shen
dc.contributor.author
Ripamonti, Raphael
dc.contributor.author
Kawabe, Hiroshi
dc.contributor.author
Ben-Yehuda Greenwald, Maya
dc.contributor.author
Werner, Sabine
dc.date.accessioned
2022-05-20T05:55:41Z
dc.date.available
2021-11-16T15:14:42Z
dc.date.available
2021-11-17T10:29:25Z
dc.date.available
2022-05-20T05:55:41Z
dc.date.issued
2022-06
dc.identifier.issn
0022-202X
dc.identifier.issn
1523-1747
dc.identifier.other
10.1016/j.jid.2021.09.033
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/515473
dc.description.abstract
The ubiquitin ligase Nedd4-1 plays key roles in organ development, tissue homeostasis and cancer, but its functions in the skin are largely unknown. Here we show perturbations in keratinocyte proliferation and terminal differentiation, epidermal barrier function, and hair follicle cycling as well as increased UV-induced apoptosis in mice lacking Nedd4-1 in keratinocytes. In particular, re-epithelialization of full-thickness excisional wounds was delayed in the mutant mice. This was caused by severely impaired migration and proliferation of Nedd4-1-deficient keratinocytes. Therefore, a few keratinocytes, which had escaped recombination and expressed Nedd4-1, obtained a growth advantage and contributed to re-epithelialization. Mechanistically, Nedd4-1-deficient keratinocytes failed to efficiently activate the Erk1/2 mitogen-activated kinases and the YAP transcriptional co-activator. These results identify Nedd4-1 as an essential player in wound repair through its effect on mitogenic and motogenic signaling pathways in keratinocytes.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.title
NEDD4-1 is a key regulator of epidermal homeostasis and wound repair
en_US
dc.type
Journal Article
dc.date.published
2021-10-28
ethz.journal.title
Journal of Investigative Dermatology
ethz.journal.volume
142
en_US
ethz.journal.issue
6
en_US
ethz.pages.start
1703
en_US
ethz.pages.end
1713.e11
en_US
ethz.grant
Fibroblast growth factor signaling in skin barrier function, wound repair and inflammatory skin disease
en_US
ethz.grant
Role of cytokines and environmental cues in wound repair and inflammatory skin disease
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
New York, NY
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
en_US
ethz.grant.agreementno
132884
ethz.grant.agreementno
169204
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.grant.program
Projekte Lebenswissenschaften
ethz.date.deposited
2021-11-16T15:14:49Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2022-05-20T05:55:49Z
ethz.rosetta.lastUpdated
2024-02-02T17:16:50Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=NEDD4-1%20is%20a%20key%20regulator%20of%20epidermal%20homeostasis%20and%20wound%20repair&rft.jtitle=Journal%20of%20Investigative%20Dermatology&rft.date=2022-06&rft.volume=142&rft.issue=6&rft.spage=1703&rft.epage=1713.e11&rft.issn=0022-202X&1523-1747&rft.au=Yan,%20Shen&Ripamonti,%20Raphael&Kawabe,%20Hiroshi&Ben-Yehuda%20Greenwald,%20Maya&Werner,%20Sabine&rft.genre=article&rft_id=info:doi/10.1016/j.jid.2021.09.033&
 Search print copy at ETH Library

Files in this item

FilesSizeFormatOpen in viewer

There are no files associated with this item.

Publication type

Show simple item record