
Open access
Date
2022-01-13Type
- Journal Article
Abstract
The prebiotic emergence of molecules capable of both self-replication and of storing information was a defining event at the dawn of life. Still, a plausibly prebiotic self-replication of biologically relevant molecules has not been demonstrated. Building upon the known templating nature of amyloids we present two systems in which the products of a peptide bond-forming reaction act as self-replicators to enhance the yield and stereoselectivity of their formation. This first report of an amino acid condensation reaction that can undergo autocatalysis further supports the potential role of amyloids in prebiotic molecular evolution as an environment-responsive and information-coding system capable of self-replication. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000516906Publication status
publishedExternal links
Journal / series
Chemistry - A European JournalVolume
Pages / Article No.
Publisher
WileySubject
Aggregation; Autocatalysis; Amyloids; Origin of life; Self-replicationOrganisational unit
03782 - Riek, Roland / Riek, Roland
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