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dc.contributor.author
Generali, Melanie
dc.contributor.author
Kehl, Deborah
dc.contributor.author
Wanner, Debora
dc.contributor.author
Okoniewski, Michał J.
dc.contributor.author
Hoerstrup, Simon P.
dc.contributor.author
Cinelli, Paolo
dc.date.accessioned
2022-01-13T16:48:14Z
dc.date.available
2021-12-04T04:50:44Z
dc.date.available
2021-12-13T14:58:27Z
dc.date.available
2022-01-13T16:48:14Z
dc.date.issued
2022-01
dc.identifier.issn
1582-1838
dc.identifier.issn
1582-4934
dc.identifier.other
10.1111/jcmm.17048
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/518636
dc.identifier.doi
10.3929/ethz-b-000518636
dc.description.abstract
The outbreak of COVID-19 has become a serious public health emergency. The virus targets cells by binding the ACE2 receptor. After infection, the virus triggers in some humans an immune storm containing the release of proinflammatory cytokines and chemokines followed by multiple organ failure. Several vaccines are enrolled, but an effective treatment is still missing. Mesenchymal stem cells (MSCs) have shown to secrete immunomodulatory factors that suppress this cytokine storm. Therefore, MSCs have been suggested as a potential treatment option for COVID-19. We report here that the ACE2 expression is minimal or nonexistent in MSC derived from three different human tissue sources (adipose tissue, umbilical cord Wharton`s jelly and bone marrow). In contrast, TMPRSS2 that is implicated in SARS-CoV-2 entry has been detected in all MSC samples. These results are of particular importance for future MSC-based cell therapies to treat severe cases after COVID-19 infection.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
adult stem cells
en_US
dc.subject
cellular therapy
en_US
dc.subject
mesenchymal stromal cells (MSCs)
en_US
dc.subject
sars-CoV-2
en_US
dc.title
Heterogeneous expression of ACE2 and TMPRRS2 in mesenchymal stromal cells
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2021-11-24
ethz.journal.title
Journal of Cellular and Molecular Medicine
ethz.journal.volume
26
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
J Cell Mol Med
ethz.pages.start
228
en_US
ethz.pages.end
234
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Hoboken
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-12-04T04:52:22Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-01-13T16:48:21Z
ethz.rosetta.lastUpdated
2022-03-29T17:31:24Z
ethz.rosetta.versionExported
true
ethz.COinS
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