
Open access
Date
2021-12Type
- Journal Article
Citations
Cited 10 times in
Web of Science
Cited 11 times in
Scopus
ETH Bibliography
yes
Altmetrics
Abstract
The host range of bacteriophages defines their impact on bacterial communities and genome diversity. Here, we characterize 94 novel staphylococcal phages from wastewater and establish their host range on a diversified panel of 117 staphylococci from 29 species. Using this high-resolution phage-bacteria interaction matrix, we unveil a multi-species host range as a dominant trait of the isolated staphylococcal phages. Phage genome sequencing shows this pattern to prevail irrespective of taxonomy. Network analysis between phage-infected bacteria reveals that hosts from multiple species, ecosystems, and drug-resistance phenotypes share numerous phages. Lastly, we show that phages throughout this network can package foreign genetic material enclosing an antibiotic resistance marker at various frequencies. Our findings indicate a weak host specialism of the tested phages, and therefore their potential to promote horizontal gene transfer in this environment. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000518939Publication status
publishedExternal links
Journal / series
Nature CommunicationsVolume
Pages / Article No.
Publisher
NatureOrganisational unit
03651 - Loessner, Martin / Loessner, Martin
Funding
167090 - Insights into the role of phages on the bacterial resistome (SNF)
659314 - Insight into the role of phages on the bacterial resistome (EC)
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Show all metadata
Citations
Cited 10 times in
Web of Science
Cited 11 times in
Scopus
ETH Bibliography
yes
Altmetrics