Preparation of Potassium Acyltrifluoroborates (KATs) from Carboxylic Acids by Copper-Catalyzed Borylation of Mixed Anhydrides
- Journal Article
We report the preparation of potassium acyltrifluoroborates (KATs) from widely available carboxylic acids. Mixed anhydrides of carboxylic acids were prepared using isobutyl chloroformate and transformed to the corresponding KATs using a commercial copper catalyst, B2(pin)2, and aqueous KHF2. This method allows for the facile preparation of aliphatic, aromatic, and amino acid-derived KATs and is compatible with a variety of functional groups including alkenes, esters, halides, nitriles, and protected amines. Show more
Journal / seriesAngewandte Chemie. International Edition
Pages / Article No.
SubjectAcylboron Compounds; Amino Acids; Carboxylic Acids; Copper; Synthetic Methods
Organisational unit03861 - Bode, Jeffrey W. / Bode, Jeffrey W.
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